Prion diseases

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Oxford University Press, 1997 - History - 205 pages
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The number of neurological conditions associated with the mutant "prion" proteins continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists, veterinary scientists, and clinicians. It has also attracted significant media attention with the recent outbreak of mad cow disease in Britain because of the potential risks to humans. This book brings together leading researchers in the field, including S. Prusiner--the researcher who first suggested that the cause of prion diseases is a protein rather than a virus. The volume represents the most up-to-date and authoritative summary available. It describes the basic structural properties of the prion protein, covers the cell biology and transgenic models of prion disease, and discusses the pathology of the diseases affecting animals and humans. The authors also provide an historical perspective and look into the future implications of current research.

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Contents

Contents
1
Human prion diseases
18
Pathology of prion diseases
57
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