Immunodeficient animals: models for cancer research
The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research.
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Predictivity Characterization and Discovery
Human Tumor Models in vitro
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angiogenesis angiogenic anti-angiogenic antibody anticancer agents Anticancer Drug Development antitumor activity apoptosis assay Basel batimastat biological Bleomycin blood bone marrow breast Burger AM eds cancer cells Cancer Res carcinoma cell lines chemotherapy cisplatin clinical trials clonogenic clonogenic assay colon compounds conjugates Contrib Oncol culture cytotoxic dose doxorubicin effect endothelial cells engraftment evaluation Fiebig HH fluorescence gastrin gene growth factor hematopoietic hollow fiber human tumor xenografts implantation inhibition inhibitors Karger leukemia lung lymphoma mammary mechanism of action melanoma metastasis mg/kg Models for Anticancer molecular mouse murine National Cancer Institute NOD/SCID mice nude mice oxaliplatin paclitaxel patients PBPC phase potential preclinical progenitor proliferation prostate receptor Relevance of Tumor renal response rituximab selected sensitive stem cells studies subcutaneously target telomerase telomerase activity telomere therapeutic therapy tissue toxicity transplantation treatment tubulin tumor cell lines tumor growth Tumor Models vascular Vinblastine vinflunine vinorelbine vitro vivo xenograft models xenografts