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Common terms and phrasesacetylators active aflatoxin agents alcohol animal antigen aromatic amines binding biotransformational blood cancer carbamazepine carcinogenic cause cell cellular cent Chapter chemical clear clinical compounds conjugates CYP enzymes CYP isoforms CYP-mediated damage dapsone detoxification dosage dose drug clearance drug failure drug levels drug metabolism electrons endogenous epoxide hydrolase ethanol Figure function gene glucuronidation grapefruit juice GSTs hapten hepatic hepatocytes hormone human CYPs hydroxylamine immune system increase inducers inhibition irreversible isoforms kidney lead lipophilic MDMA metabolites methaemoglobin molecules morphine NADPH neonates occur oestrogen OH H OH OH opiates organ overdose oxidation oxygen P-glycoprotein paracetamol parent drug patients Phase phenobarbitone phenytoin plasma levels polymorphisms poor metabolizers potent inhibitor problem protein reactions reactive species receptor reduced reductase response rifampicin SSRIs stable steroid structure studies substrate sulphate sulphonamides SULTs terfenadine therapeutic window therapy tion tissues toxicity toxins UGTs urine usually warfarin water-soluble xenobiotic Bibliographic information
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