Degeneration and Regeneration in the Nervous System

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Norman Saunders, Katarzyna Dziegielewska
CRC Press, Sep 2, 2003 - Medical - 348 pages
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Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient.
With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
  

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Contents

A clinical perspective
1
2 Recovery from injury in the immature mammalian spinal cord
17
3 Intrinsic determinants of differential axonal regeneration by adult mammalian central nervous system neurons
53
Factors at the site of injury that influence regeneration in the central nervous system
76
5 Intrinsic neuronal and extrinsic glial determinants of axonal regeneration in the injured spinal cord
93
Implications for cell survival axon outgrowth and map formation
120
7 The role of cytoskeleton in regeneration of central nervous system axons
157
8 What types of bridges will best promote axonal regeneration across an area of injury in the adult mammalian spinal cord?
175
9 Use of cellpolymer hybrid structures as conduits for regenerative growth in the central nervous system
195
Regulation and potential use in neuronal regeneration
209
A multifunction molecule with a role in nerve regeneration?
226
12 Regeneration in the peripheral nervous system
244
13 The role of macrophages in degeneration and regeneration in the peripheral nervous system
268
14 The response of the somatosensory system to peripheral nerve injury
291
Index
323
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About the author (2003)

Jeremy Friedman, MD, MBChB, FRCP(C) is the Chief of Pediatric Medicine at The Hospital for Sick Children and an associate professor, pediatrics, at the University of Toronto.

Norman Saunders, MD, FRCP(C) is a staff pediatrician at The Hospital for Sick Children and an associate professor at the University of Toronto.

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