DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, Volume 2

Front Cover
Vincent T. DeVita, Theodore S. Lawrence, Steven A. Rosenberg
Lippincott Williams & Wilkins, 2008 - Medical - 3151 pages
1 Review

Acclaimed by the worldwide medical community as "a staple reference text in the medical oncologist's library" (JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology is now in its Eighth Edition. This edition is in full color for the first time, has a new editor, Theodore S. Lawrence, MD, PhD, a radiation oncologist, and has two Associate Scientific Advisors, Ronald A. DePinho, MD and Robert A. Weinberg, PhD, with special expertise in molecular biology. More than 40 chapters are entirely new, and more than 70 have been rewritten by new contributing authors. Plus, this edition has an exciting new companion Website.

The text provides cutting-edge, practical information on the science of oncology and the multimodality treatment of every cancer type. To ensure a balanced, multidisciplinary approach, each major treatment chapter is co-authored by a surgeon, a medical oncologist, and a radiation oncologist. Treatment of each cancer type is discussed by stage, with coordinated guidelines on the role of each treatment modality at each stage. Each major treatment section is preceded by an updated brief chapter describing the molecular biology of the cancer and the implications of molecular biology for patient management. Full consideration is also given to cancer prevention, screening, palliative care, supportive oncology, and quality of life issues.

A companion Website offers the fully searchable online text, an image bank, links to journal articles, and a question bank.

  

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Contents

VOLUME
1487
Principles of Immunotherapy 351
1491
Cancer Screening 659
1496
Staging 1134
1501
Potential Clinical Applications of Molecular Advances 1230
1518
Invasion and Metastasis 117
1521
Carcinoma of the Vulva
1528
Sections Cancer of the Uterine Body
1543
Stem Cell Transplantation
2541
Conditioning Regimens
2549
Sources of Allogeneic Hematopoietic Stem Cells
2557
Future Prospects
2565
Management of Adverse Effects of Treatment
2617
Vascular Events
2634
Nausea and Vomiting Syndromes
2640
Antiemetic Agents
2642

Uterine Sarcomas
1557
Gestational Trophoblastic Diseases
1564
Test Validity 660
1572
Colon Cancer 1232
1574
Epothilones 455
1586
Genetic Predisposition 1390
1595
Her Family 469
1601
Cancer Stem Cells 135
1604
Malignant Tumors of the Breast
1606
Diagnosis and Biopsy
1612
Local Management of Invasive Cancer
1620
Prognostic and Predictive Factors
1632
Integration of Multimodality Primary Therapy
1640
Screening Populations at High Risk of Hepatocellular Carcinoma 1139
1644
Cancer of the Endocrine System
1655
Thyroid Tumors
1663
Parathyroid Cancer
1682
Adrenal Tumors
1690
Pheochromocytomas
1697
Genetic and Environmental Risk Factors 1233
1700
Tumor Classification Histopathology and Molecular Genetics
1703
Cholangiocarcinomas 1157
1712
Natural History and Patterns of Failure 1000
1713
Small Cell Lung Cancer 946
1717
Emerging Therapeutic Options
1718
Incidence 1186
1720
Clinical Presentation 1001
1723
Typical Carcinoid and Atypical Carcinoid 963
1724
Treatment of the Carcinoid Tumor
1731
Alkylating Agents 407
1733
Familial Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Types 2A and 2B
1738
Gastrointestinal Stromal Tumors 1204
1741
TNFRelated ApoptosisInducing Ligand 474
1750
Immunoglobulin Structure 538
1771
Sarcomas of Bone
1794
Biopsy Technique and Timing
1801
Chemotherapy for Bone Sarcomas
1807
Background 549
1823
Benign and Malignant Mesothelioma
1835
Solitary Fibrous Tumors of Pleura
1841
Photodynamic Therapy 766
1852
Malignant Peritoneal Mesothelioma
1856
Cancer of the Skin
1863
Melanoma
1889
Integrins 475
1893
Diagnostic Studies and Pretreatment Staging 1001
1908
Conclusions 475
1912
Intraocular Melanomas
1951
Metastatic WorkUp
1957
Posttreatment Quality of Life
1963
Epigenetics and Gene Silencing 478
1974
Neoplasms of the Central Nervous System
1975
Histopathologic Features and Histogenesis 1204
1978
Neurodiagnostic Tests
1981
Specific Central Nervous System Neoplasms
1988
Gliomatosis Cerebri
1996
Treatment 1003
2029
Cancers of Childhood
2033
Solid Tumors of Childhood
2043
Wilms Tumor
2050
Osteosarcoma and Ewings Sarcoma
2057
Rhabdomyosarcoma
2067
Infectious Agents and Cancer 549
2071
Germ Cell Tumors
2074
Lymphomas
2085
Historical Perspectives 407
2088
Neoplasms of the Mediastinum 973
2096
NonHodgkins Lymphomas
2098
Principles of the World Health Organization Classification of Lymphoid Neoplasms
2106
Specific Disease Entities
2114
Special Clinical Situations
2136
Cutaneous TCell Lymphomas
2143
Principles of Therapy of Mycosis Fungoides and the Sezary Syndrome
2149
Autologous and Allogeneic Bone Marrow Transplantation
2155
Management and Therapy
2161
Hodgkin Lymphoma
2167
Nodular Lymphocyte Predominance Hodgkin Lymphoma
2174
Acute Leukemias
2221
Deletions and Numeric Abnormalities in Acute Leukemias
2227
Acute Myelogenous Leukemia
2233
Stem Cell Transplantation for Acute Myelogenous Leukemia
2243
Acute Lymphoblastic Leukemia
2255
Chronic Leukemias
2267
Myelodysplastic Syndromes
2292
Therapy
2298
Plasma Cell Neoplasms
2305
Alkylating AgentSteroid Conjugates 416
2311
Clinical Manifestations
2313
Changes in DNA Methylation 478
2319
Differential Diagnosis
2322
Paraneoplastic Syndromes
2343
Cutaneous Manifestations of Cancer 2 349
2349
Approach to the Patient with Paraneoplastic Neurologic Disease
2359
Gastrointestinal Cancers 664
2376
Summary 668
2384
Diagnosis 1237
2389
Treatment
2396
Common Features of Platinum Chemistry 420
2401
Kaposis Sarcoma
2404
Screening 1238
2405
Hodgkins Lymphoma
2413
Pathology and Tumor Biology 1046
2415
Human Papillomavirus 552
2417
Lymphomas
2423
Increased Intracranial Pressure
2435
Spinal Cord Compression
2441
Hyperuricemia
2448
Urologic Emergencies
2455
Treatment of Metastatic Cancer
2461
Gynecologic Cancers 670
2490
Rectal Cancer 1285
2501
Staging 1286
2508
Metastatic Cancer to the Bone
2510
Controlling Side Effects of Treatment
2516
Malignant Effusions of the Pleura and Pericardium
2523
Malignant Ascites
2533
Specific Management Guidelines
2650
Antimetabolites 427
2655
Radiation TherapyRelated Complications
2656
Indirect Cytoprotectants
2662
Studies of Health Service Delivery in Cancer Medicine 369
2665
Pulmonary Toxicity
2668
Pemetrexed 428
2678
Conclusion
2686
Anatomy and Physiology
2689
Effects of Cytotoxic Agents on Adult Women
2695
Prevention and Management of Erectile and Ejaculatory Dysfunction
2706
Principles of Oncology
2711
Evaluation of the Patient with CancerRelated Fatigue
2712
Epidemiology of Tobacco and Cancer 147
2717
Second Cancers
2718
Pharmacology of Cancer Chemotherapy 385
2722
Colorectal Cancer Epidemiology and Pathobiology 1218
2730
Conclusion
2739
Goals of Survivorship Health Care
2745
Neurocognitive Effects
2751
Supportive Care and Quality of Life
2757
Classification of Patients with Cancer Pain
2763
Management of Cancer Pain
2769
Psychological Approaches
2780
Neurostimulatory Procedures
2786
Colon Cancer 240
2788
Weight Loss and Cancer Cachexia
2792
Ethical and Legal Aspects of Nutrition Support
2803
Pharmacology of Endocrine Manipulation 557
2806
Endometrial Cancer 241
2808
Prostate Cancer
2810
Cancer of the Prostate 1392
2811
Assessing Sexual Function
2814
Outcome
2822
Explanations
2828
Care Without Chemotherapy
2834
The Final Days
2843
Rehabilitation of the Cancer Patient
2857
Sl 431
2882
Societal Issues in Oncology
2885
EndofLife Care
2895
Cancer Genetics
2902
Photosensitizers Light and Oxygen 767
2905
Developing and Selecting Quality Indicators and Measures
2908
Regulatory Issues
2914
Drug Safety Reporting and Evaluation
2920
Design and Analysis of Clinical Trials 571
2924
Race and Cancer
2928
Information Systems in Oncology
2935
Complementary Alternative and Integrative Therapies
2949
Specific Complementary and Alternative Medicine Therapies
2955
Newer Approaches in Cancer Treatment
2965
Cancer Gene Therapy Applications
2972
STEVEN A ROSENBERG
2979
Focused Ultrasound
2991
RNA Inhibition
3001
Historical Perspective 283
3002
Charged Particle Therapy
3013
Gleason Score 1394
3018
Surgery 1288
3021
Anesthesia for Oncologic Surgery 284
3025
Total Mesorectal Resection 1290
3029
Nanotechnology
3031
Cytarabine 431
1
Biomarkers 774
4
Principles of Cancer Susceptibility 157
5
Incidence Epidemiology and Risk Factors 1395
7
Adenocarcinomas of the Esophagus 241
12
Genomics and Proteomics
13
Early DetectionScreening 1399
14
Topisomerase Biology 437
15
Genetic Testing 159
16
Ovarian Cancer 674
26
Physiology of Laparoscopy 293
29
KidneyRenal Cell Cancer 242
30
Gene Silencing 479
32
Destabilization of the Cancer Genome
35
Anthracyclines 440
36
Principles of Radiation Oncology 307
37
Disease Presentation and Diagnosis 1400
38
Bronchoscopy 790
40
Functional Imaging 733
43
Gallbladder Cancer 242
44
Cancer Susceptibility Syndromes 160
45
Incidence 1463
46
Chemoprevention 609
47
Histone Deacetylase Inhibitors 481
49
Telomeres Telomerase and Cell Immortalization
53
Hepadnaviruses and Hepatocellular Carcinoma 178
56
Interleukin Therapy 506
58
Section3 Cancer of the Kidney 1331
63
Screening for Lung Cancer 681
65
Cell Signaling
67
Principles of Medical Oncology 337
68
Tumor Immune Surveillance 191
69
Microtubules 447
71
Formation of Multiprotein Signaling Complexes
74
Asbestos 223
77
Cell Cycle
80
Common Molecular Changes 1080
81
Lung Cancer 243
82
Pharmacogenomics 402
84
Restriction Point
86
Proteasome Inhibitors 486
88
Senescence
93
Introduction 527
94
Initial Presentation and Management 1463
95
Drugs for Chemoprevention 626
96
Small Cell Cancers 1311
97
Role of Autophagy in Tumor Suppression
99
Taxanes 447
102
Dysfunctional Nature of the Tumor Vasculature
105
Cancer Surveillance Systems 276
107
New Taxane Formulations 451
109
Genetic Counseling 651
110
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About the author (2008)

DeVita is Amy and Joseph Perella Professor of Medicine, Yale Cancer Center, Yale University School of Medicine; Professor of Epidemiology and Public Health, Yale University School of Public Health, New Haven, Connecticut.

Rosenberg is Chief of Surgery, National Cancer Institute, National Institutes of Health; Professor of Surgery, Uniformed Services University of the Health Sciences School of Medicine, Bethesda, Maryland; Professor of Surgery, George Washington University School of Medicine, Washington, DC.

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