PsychopharmacogeneticsBasil Eleftheriou This short volume of an apparently double hybrid science deals with major pharmacologic effects on behavior in genetically defined animal and, to a lesser extent, human populations. Thus, a new name, psychopharmacogenetics, was coined to designate its contents. The necessity for such compilation of some of the major data has become increasingly urgent. For some time now, there has been available information dealing with pharmacogenetics and behavior genetics. Recently, with ever-increasing frequency, however, data have been accumulating that deal with the effects of specific drugs on behavior and behavioral responses in animals with known genetic background. Initially, the data were gathered in various species and in a number of strains within given species of animals. With the availability of mutations, inbred strains, segregating strains of various types, recombinant inbred strains and congenic lines, the experimental approach to psychopharmacogenetics has now reached a new peak of sophistication. This volume attempts to present some of the major experiments in this area, along with comprehensive sur vey of the status of a given drug. It is hoped that reading of the information that has been com piled herein will ultimately lead to a stimulus for further research in the areas outlined, as well as make the reader acquainted with new approaches to drug:behavior:genetic research. Basil E. Eleftheriou June, 1975 v CONTENTS Introduction. • • • • • • . . . . . . . . . . . . . . . 1 Basil E. Eleftheriou Genes and Drugs as Behavior Modifying Agents. |
Contents
IMPLICATIONS OF PSYCHOPHARMACOGENETICS RESEARCH | 34 |
Implications of Psychopharmacogenetics Research | 35 |
Conclusions | 40 |
Copyright | |
16 other sections not shown
Other editions - View all
Common terms and phrases
acoustic priming action activity administration agents alcohol amphetamine analysis anesthesia anesthetic animals apomorphine appear approach audiogenic seizures avoidance behavior biochemical blood brain central changes chronic compared concentration correlations dependent depression determined differences doses drinking drug effects Eleftheriou Elias et al ethanol ether evidence example experimental experiments factors findings function gene genetic genotype given halothane human hybrids important inbred strains increase indicate individual induced influence injection interaction involved learning levels lines means measurements mechanisms memory metabolism method mg/kg mice morphine mouse multivariate nature normal noted observed Oliverio patients patterns performance period Pharmacol possible present Press produced rats relationship relative reported response RI strains running scores selected sensitivity showed significant similar single species stereotypies stimulation strains studies subjects suggest susceptibility Table tion treatment trial variables variance variation various