An introduction to clinical research in psychiatry
The evaluation of psychiatric disorders and the delivery of mental health services is grounded in clinical research. Findings from published studies in scientific journals are translated by clinicians into changes in daily practice. Psychiatrists and other mental health professionals read original research reports and case studies in journals, and often attend scientific meetings where the latest research findings are presented. Yet despite their extensive education and experience, most psychiatrists do not have sufficient training in clinical research methods to evaluate critically the latest findings.
Blazer and Hays have written this primer to acquaint practitioners and residents with the basic methodology of study design. The book covers single-subject studies, description studies (such as case registers and population-based surveys), community surveys, cohort and case-control studies, longitudinal studies, population genetic studies and clinical trials. The focus is on clinical research in which the patient is the unit of analysis. The two authors write in clear style, uncluttered by technical jargon, so that their book will be accessible to readers with little or no grounding in clinical research methods. The theoretical presentation is illustrated with examples from published studies which highlight the problems typically encountered by clinicians involved in patient-oriented research in psychiatry.
Introduction to Clinical Research in Psychiatry employs an interactive, problem-based approach to introducing epidemiologic methods, which has been successfully tested in a course the authors taught at the Duke University School of Medicine. The book is designed primarily for mental health care professionals with little experience in research methods, including psychiatrists, psychologists, social workers, nurses, and others working in mental health centers, hospitals, and psychiatric ambulatory care centers.
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Diagnostic Tests and Screening Instruments
Population Genetics Studies
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affective disorder Alzheimer's disease analysis anxiety assessment associated authors bipolar disorder case-control study Chapter clinical depression clinical trial clinicians cohort design community-based Comorbidity compared confounding cortisol criteria Depression Study depressive disorder depressive episode described descriptive studies determine diagnostic test drug effects Egeland environmental estimate example fluoxetine follow-up frequency gender gene genetic haloperidol Health Statistics homelessness hospital hypotheses identified incidence included individual interval interview investigators Journal of Psychiatry logistic regression longitudinal studies major depression measures medication melancholia Mental Health methods methylphenidate monozygotic mood disorder mortality multiple negative nortriptyline odds ratio onset outcome patients pedigree studies persons phenelzine placebo population potential prevalence psychiatric disorders Psychobiology of Depression reader regression risk factors sample scale schizophrenia scores screening selected specific status Stirling County Stirling County Study stressful events stressful life events study design subjects survey Table tardive dyskinesia therapy treatment zygosity