Holland Frei Cancer Medicine Eight, Volume 8

Front Cover
Waun Ki Hong, American Association for Cancer Research, William N. Hait
PMPH-USA, 2010 - Medical - 2021 pages
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The consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists and others who treat cancer patients, Cancer Medicine 8 covers the ever-widening sphere of current cancer knowledge and clinical practice.

In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging and therapy.

The book is a testament to the editorial panel's creed that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. Cancer Medicine 8 does a superb job of bringing scientific principles into clinical practice. This text is the ultimate resource of new information providing the basis for better informed cancer therapy choices.

Cancer Medicine 8 features hundreds of 4-color illustrations, photographs, tables, graphs and algorithms that make this text an invaluable clinical tool in recognizing characteristic appearances of both patient and tissue.

The 137 tightly focused chapters are organized into 5 sections:

I: Cardinal Manifestations of Cancer
II: Scientific Foundations of Cancer
III: Principles of Cancer Diagnosis
IV: Principles of Therapeutic Modalities
V: Principles of Multidisciplinary Management

Major Revisions:

Chapter 6: Oncogenes An entire section is devoted to oncogenes like kit, Ret, Braf, Akt genes and the new drugs that specifically target them. This chapter not only provides a list of these new therapies but also insight as to how they target the oncogenes and their mutations, as well as therapy response and efficacy.
Chapter 11: Tumor Angiogenesis This chapter provides a wealth of new data and understanding of the mechanisms of angiogenesis and how it contributes to the malignancy of various cancers The Clinical Advancement section provides an extensive summary of new trials investigating numerous novel angiogenesis agents
Chapter 33: Chemoprevention This chapter also provides a considerable amount of new information for a broad range of clinical trials such as the HPV vaccine trial Future, Select, Star, Approve and PreSAP. The rationales for these trials are discussed and resulting data from the completed trials are presented.
Chapter 55: Cytokines Research on cytokines is another area that is exploding in magnitude. This chapter presents a wealth of new information on promising new therapeutic agents.There is also updated information on the therapeutic usage of currently available agents such as hemotopoietic growth factors (HGF), erythropoietin and thromobopoietic agents.
Chapter 56: Monoclonal Serotherapy A considerable amount of research has been done in the past few years on therapeutic and targeted agents in cancer therapy. Updated information and data is provided from recent trials for therapies previously discussed in Cancer Medicine edition 7 covering therapeutic agents and targeted toxins.
Chapter 77: Neoplasms of the Head and Neck There is a discussion of changes in treatment methods for certain cancers such as the recent shift from surgery to combined chemotherapy with radiotherapy for tonsillar cancer, nasal and paranasal sinuses cancers and laryngeal cancer.
Chapter 78: Lung Cancer Advances in diagnostic techniques are described such as ultrasound-guided fine needle aspiration or electromagnetic navigation diagnostic bronchoscopy. Video assisted thoracoscopic surgery (VATS) discussion is updated. New sections are devoted to prognostic and predictive biomarkers.

  

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Contents

I
1
II
5
IV
26
V
40
VI
51
VII
68
VIII
86
IX
102
LXXII
899
LXXIII
904
LXXIV
915
LXXV
923
LXXVI
933
LXXVII
940
LXXVIII
959
LXXIX
999

X
125
XI
141
XII
149
XIII
170
XIV
175
XV
190
XVI
225
XVII
237
XVIII
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XIX
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XX
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XXI
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XXIII
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XXIV
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XXV
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XXVII
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XXVIII
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XXIX
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XXX
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XXXI
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XXXII
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XXXIII
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XXXIV
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XXXVII
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XXXVIII
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XL
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XLI
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XLII
510
XLIII
528
XLIV
541
XLV
550
XLVI
558
XLVII
568
XLVIII
587
XLIX
597
L
611
LI
621
LII
633
LIII
645
LIV
655
LV
679
LVI
686
LVII
710
LVIII
725
LIX
737
LX
750
LXI
759
LXII
776
LXIII
793
LXIV
810
LXV
823
LXVI
830
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LXVIII
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LXIX
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LXX
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LXXI
881
LXXX
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LXXXI
1053
LXXXII
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LXXXIII
1067
LXXXIV
1074
LXXXV
1086
LXXXVI
1109
LXXXVII
1124
LXXXVIII
1132
LXXXIX
1144
XC
1172
XCI
1194
XCII
1204
XCIII
1212
XCIV
1219
XCV
1228
XCVI
1255
XCVII
1263
XCVIII
1289
XCIX
1299
C
1325
CI
1338
CII
1344
CIII
1376
CIV
1384
CV
1393
CVI
1459
CVII
1487
CVIII
1497
CIX
1517
CX
1544
CXI
1559
CXII
1582
CXIII
1591
CXIV
1604
CXV
1622
CXVI
1645
CXVII
1659
CXVIII
1668
CXIX
1686
CXX
1696
CXXI
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CXXII
1723
CXXIII
1740
CXXIV
1757
CXXV
1763
CXXVI
1779
CXXVII
1788
CXXVIII
1797
CXXIX
1813
CXXX
1823
CXXXI
1832
CXXXII
1849
CXXXIII
1871
CXXXIV
1880
CXXXV
1891
CXXXVI
1901
CXXXVII
1915
CXXXVIII
1921
CXXXIX
1941
CXL
1961
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About the author (2010)

Waun Ki Hong, MD Division Head Thoracic Head & Neck Medical Oncology, MD Anderson Cancer Center

Donald W. Kufe, MDProfessor of MedicineDana Farber Cancer InstituteHarvard Medical School

Robert C. Bast Jr, MDVice President for Translation ResearchMD Anderson Cancer Center

William Hait, MD, PhDSenior VP and Worldwide Head Ortho Biotech Oncology Research & Development (ORD), Johnson & Johnson Pharmceutical Research & Development

Raphael E. Pollock, MD, PhDHead of the Division of Surgery, Professor and Chairman of the Department of Surgical Oncology, Senator A. M. Aiken, Jr. Distinguished Chair M. D. Anderson Cancer Center

Ralph R. Weichselbaum, MDDaniel K. Ludwig ProfessorChair Dept of Radiology and Cellular OncologyUniversity of Chicago HospitalDirector Chicago Tumor Institute

James F. Holland, MD, ScD (hc)Director Emeritus, Derald H. Ruttenberg Cancer CenterMount Sinai School of Medicine

Emil Frei, III, MDPhysician in Chief EmeritusDana Farber Cancer Institute

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