WHO Classification of Tumours of the Central Nervous System

Front Cover
International Agency for Research on Cancer, 2007 - Medical - 309 pages
6 Reviews
WHO Classification of Tumours of the Central Nervous System is the first volume of the 4th Edition of the World Health Organization series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.

Diagnostic criteria pathological features and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors.

This book is in the series commonly referred to as the "Blue Book" series.


The book prepared by 73 authors from 19 countries contains more than 400 color photographs, numerous X-rays, computed tomography (CT), magnetic resonance (MR) images, charts and more than 2,500 references.



...The title of this book is typically modest. It is not only a classification of tumours of the central nervous system but an authoritative and explicit account of this group of tumours...This the fourth edition contains a number of distinct improvements on previous editions both in layout and content... One new feature is the clear account of the WHO's grading system its rationale and its application... New tumour entities are included...Newly recognized histological variants include pilomyxoid astrocytoma. Both anaplastic medulloblastoma and medulloblastoma with extensive nodularity have gained recognition in the classification... There are some differences in classification from the third edition most notably relating to anaplastic oligoastrocytoma. The change in emphasis follows cited differences in prognosis between mixed tumours with and without necrosis. Other changes are also apparent e.g. within the atypical teratoid/rhabdoid section mention of the INI-1 locus in the genetics section in the third edition has been expanded to include immunohistochemistry in the fourth edition. The fourth edition is unique in its clear-targeted and succinct style of presentation of tumors of the CNS... it will be of universal appeal in neuro-oncology and will most certainly form the main basis for diagnosis by multidisciplinary teams managing patients with tumors of the CNS."

-- Nicki Cohen* and Roy O. Weller** *Specialist Registrar in Neuropathology Southampton University Hospital NHS Trust UK.

** Emeritus Professor of Neuropathology Southampton University UK in
Neuropathology and Applied Neurobiology.



...Representing the first volume in the fourth edition series of the World Health Organization (WHO) Classification of Tumours this book provides a welcome mix of old and new. ... Perhaps the most noticeable improvement comes by way of a voluminous expansion in the genetics sections of the majority of tumor categories. This update parallels the recent explosion of research utilizing high-resolution genome screening and other molecular techniques. The authors have done an outstanding job in distilling the information housed in over 2,500 cited references into a reader friendly authoritative reference of CNS neoplasia. In summation, the current edition of the WHO Classification of Tumours of the Central Nervous System will serve as an indispensable textbook for all of those involved in the diagnosis and management of patients with tumors of the CNS and will make a valuable addition to libraries in pathology, radiology, oncology and neurosurgery departments.

--Journal of Neuropathology & Exp. Neurol.


Contributors:Dr. Kenneth D. Aldape, Dr. Cristina R. Antonescu, Dr. Albert J. Becker, Dr. Jacklyn A. Biegel, Dr. Wojciech Biernat, Dr. Darell D. Bigner, Dr. Ingmar Blümcke, Dr. Fredrik T. Bosman, Dr. Sebastian Brandner, Dr. Daniel J. Brat, Dr. Herbert Budka, Dr. Peter C. Burger,Dr. Webster K. Cavenee, Dr. Leila Chimelli, Dr. V. Peter Collins, Dr. Catherine Daumas-Duport, Dr. Martina Deckert, Dr. Charles G. Eberhart, Dr. David W. Ellison, Dr. Charis Eng, Dr. Dominique Figarella-Branger, Dr. Gregory N. Fuller, Dr. Felice Giangaspero, Dr. Caterina Giannini, Dr. Hannu Haapasalo, Dr. Pierre Hainaut, Dr. Johannes A. Hainfellner, Dr. Volkmar H. Hans, Dr. Cynthia Hawkins, Dr. Stephen Hunter, Dr. Anne Jouvet, Dr. Alexander R. Judkins, Dr. Paul Kleihues, Dr. Andrey Korshunov, Dr. Johan M. Kros, Dr. Arielle Lellouch-Tubiana, Dr. Suet Yi Leung, Dr. Pawel Liberski, Dr. M. Beatriz S. Lopes, Dr. David N. Louis, Dr. Masao Matsutani, Dr. Roger E. Mclendon, Dr. Yoichi Nakazato, Dr. Hartmut P.H. Neumann, Dr. Ho-Keung Ng, Dr. Hiroko Ohgaki, Dr. Magali Olivier, Dr. Werner Paulus, Dr. Arie Perry, Dr. Torsten Pietsch, Dr. Karl H. Plate, Dr. Matthias Preusser, Dr. Guido Reifenberger, Dr. Federico Roncaroli, Dr. Marc K. Rosenblum, Dr. Elisabeth J. Rushing, Dr. Chitra Sarkar, Dr. Bernd W. Scheithauer, Dr. Davide Schiffer, Dr. Sursala K. Shankar, Dr. Mehar C. Sharma, Dr. Dov Soffer, Dr. Figen Söylemezoglu, Dr. Anat O. Stemmer-Rachamimov, Dr. Ana Lia Taratuto, Dr. Tarik Tihan, Dr. Erwin G. Van Meir, Dr. Scott R. Vandenberg, Dr. Andreas Von Deimling, Dr. Alexander O. Vortmeyer, Dr. Pieter Wesseling, Dr. Otmar D. Wiestler, Dr. James M. Woodruff, Dr. David Zagzag










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About the author (2007)

The International Agency for Research on Cancer (IARC) is part of the World Health Organization. IARC's mission is to coordinate and conduct research on the causes of human cancer, the mechanisms of carcinogenesis, and to develop scientific strategies for cancer control. The Agency is involved in both epidemiological and laboratory research and disseminates scientific information through publications, meetings, courses, and fellowships.