An Intraoperative Beta−Probe for Cancer SurgeryThis thesis focuses on a novel radio-guided surgery technique for complete tumor resections. It describes all aspects of the intraoperative probe, as well as testing and simulation of the novel technique. The presentation develops the technique from the initial idea to realistic feasibility studies that have been the subject of a press release of the American Society of Nuclear Medicine. Just a year after completing this work, the technique has now been tested for the first time on a meningioma patient, confirming all of the predictions made in this thesis. |
Contents
| 1 | |
2 The FLUKA Monte Carlo Code | 19 |
3 Design and Tests of the Probe | 27 |
4 Medical Applications | 53 |
5 Evaluation of Probe Performances | 85 |
6 Conclusions | 97 |
Curriculum Vitae | 99 |
Other editions - View all
Common terms and phrases
applications background benign Beta-Probe for Cancer brain surgery bremsstrahlung Cancer Surgery cerebral tumors chemotherapy Collamati decay described in Sect Despite detection detector DICOM dose dosimetry DOTATOC effect electrons emission emitted energy deposited evaluate example FDGDS files FLUKA function gamma Gamma Knife Glioblastoma Glioblastoma multiforme glioma grade healthy tissue interactions Intraoperative Beta-Probe isotope kBq/mL lesions light attenuation length malignant malignant meningioma measured meningioma molecule Neuroendocrine Tumors Nucl nuclear obtained optical fiber optical photons optimization p-terphenyl samples particles patients affected PET scans phantom photons positron Positron Emission Tomography possible probe prototypes ProbeSiPm PRRT radiation Radio Guided Surgery radioactive radiopharmaceutical radiotherapy receptors resection ROIs scintillation scintillation light sensitive sentinel lymph node setup showed in Fig signal simulation somatostatin spatial resolution specific activity spectrum surgeon surgical technique Therapy Thesis threshold tracer treatment uptake voxel