From Molecules to Medicines: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and BioterrorismJoel L. Sussman, Paola Spadon Proceedings of the NATO Advanced Study Institute on Integrating Crystallography in the Fight Against Terrorism Erice, Italy 29 May-8 June 2008 |
Contents
| 1 | |
STRUCTURAL BIOLOGY CONTRIBUTIONS | 37 |
INTEGRATING CRYSTALLOGRAPHY INTO EARLY | 63 |
THE FOUNDATIONS OF PROTEINLIGAND INTERACTION 79 | 78 |
STRUCTUREBASED DESIGN OF TRNAGUANINE | 103 |
PROTEIN STRUCTURE MODELING | 139 |
STRUCTURAL BIOLOGY AND MOLECULAR MODELING | 152 |
TOOLS TO MAKE 3D STRUCTURAL DATA MORE | 169 |
STRUCTURAL STUDIES ON ACETYLCHOLINESTERASE | 183 |
PROTEIN FUNCTION PREDICTION FROM STRUCTURE | 201 |
CRYSTAL STRUCTURES OF THE β2ADRENERGIC RECEPTOR 217 | 216 |
CAN STRUCTURES LEAD TO BETTER DRUGS? LESSONS | 231 |
Other editions - View all
From Molecules to Medicines: Structure of Biological Macromolecules and Its ... Joel L. Sussman,Paola Spadon No preview available - 2009 |
From Molecules to Medicines: Structure of Biological Macromolecules and Its ... Joel L. Sussman,Paola Spadon No preview available - 2009 |
From Molecules to Medicines: Structure of Biological Macromolecules and Its ... Joel L. Sussman,Paola Spadon No preview available - 2009 |
Common terms and phrases
3D structure Abl kinase acetylcholinesterase active conformation amino acid antibiotics atom BCR-Abl binding affinity binding mode binding pocket Biochem Biol buffer C-terminal catalytic cell Chem chemical chemistry complex compounds computational contribution Cowan-Jacob crystal structure crystallography DFG motif DFG-out dimer DPP-4 inhibitors drug design drug discovery eMovie enthalpic entropic enzyme Figure formation fragment fragment-based function Gibbs free H-bonds hepatitis C virus homology models hydrogen bond hydrophobic imatinib inactive conformation inhibition kinase domain kJ/mol ligand ligand binding lipophilic Manley metabolism metabolite MetaSite methods moiety molecular mutations Mycobacterium tuberculosis nilotinib NS5A optimisation P-loop peptide PON1 position potential prediction protease protein and ligand protein structure protein-ligand interactions Proteopedia reaction receptor region residues ribosome screening selectivity sequence side chain sitagliptin sortase stability structural biology structural genomics structure-based substrate subunit surface target tRNA tyrosine kinase water molecules