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acid agglomeration ammonium antisolvent Applied Chemistry aqueous solutions barium batch crystallization calcium carbonate caprolactam Cedex Chemical Engineering Chemical Technology chloride coefficient compound concentration cooling crystallization crystal growth rate crystal morphology crystal size distribution crystallisation crystallization process Delft Department of Chemical dissolution E-mail effect energy ethanol eutectic experimental data experiments flow formation France Germany gibbsite Halle-Wittenberg Heriot-Watt University impurity industrial crystallization influence Institute of Technology investigated Japan jarosite Keywords kinetics Lappeenranta layer measured mechanism melt crystallization metastable metastable zone width method micromixing mixing mixtures Netherlands nucleation obtained operating conditions oxalate P.O. Box paracetamol parameters particle size distribution pharmaceutical phase polymorphs potassium precipitation process predicted primary nucleation purification reactant reactive crystallization reactor Research Rosmalen scale secondary nucleation seed seed crystal simulation sodium sodium perborate solid solubility solvent sulfate sulphate supercritical supersaturation surface suspension technique temperature turbulent UMIST University of Bradford University of Technology vanillin