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Pharmacokinetic and metabolic studies with 4hydroxy
R Shearer and J H Davies
Effect of treatment with 4hydroxyandrostenedione on aromatase
250 mg intramuscularly 4-hydroxyandrostenedione 4-OHA 4-Hydroxyandrostenedione—a new approach advanced breast cancer aminoglutethimide androgen androstenedione antioestrogen approach to hormone-dependent aromatase activity aromatase inhibitors breast cancer breast tumour Brodie AMH Cancer Res clinical Congress and Symposium Coombes RC DNA polymerase DNA polymerase alpha Dowsett drug edited by R. C. effects of 4-OHA endocrine therapy endocrine treatment glucuronide goserelin hormone hormone-dependent cancer incubation inhibition intramuscular injection intramuscularly L0nning luteinizing hormone Medicine Services International Medicine Services Limited metabolites metastatic objective response oestrogen receptor oestrone concentration oestrone sulphate Oncology patients with breast peripheral aromatization pharmacokinetics plasma plasma oestradiol levels polymerase alpha activity postmenopausal breast cancer postmenopausal women Powles TJ premenopausal patients pretreated progestins prostatic cancer published by Royal R. C. Coombes response rate Royal Marsden Hospital Royal Society serum oestradiol Services International Congress Society of Medicine St George's Hospital steroid Symposium Series tamoxifen treatment with 4-OHA trials tumour UK SUMMARY urinary vitro vivo weeks