5-Hydroxytryptamine in Psychiatry: A Spectrum of Ideas
Research on 5-hydroxytryptamine (5-HT) has exploded over the past decade and nowhere have the implications been more far-reaching than in psychiatry. Through the introduction of radioligand binding techniques, a bewildering variety of central 5-HT receptors has been revealed, and powerful new families of centrally active drugs have emerged. For example, our understanding of and the treatment for obsessive-compulsive disorder has been transformed in a very few years. This book is the result of a meeting of the Collegium Internationale Neuro-Psychopharmacologicum. Its free-ranging cut and thrust and the many good ideas presented cannot fail to be of interest to neuroscientists, pharmacologists, psychiatrists, and all those who wish to keep abreast of this rapidly moving area of research.
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List of contributors
An overview of serotonin neurochemistry
Arora R C
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5-HT receptor 5-HT uptake 5-HT1A agonists 5-hydroxytryptamine acid activity affective disorders affinity antagonists anxiety anxiogenic anxiolytic Archives behaviour benzodiazepines binding sites Biological Psychiatry blood platelets Bmax brain Briley British Journal buspirone chronic clinical clomipramine clorgyline concentrations controls Coppen correlation cortisol Cowen CSF 5-HIAA Curzon Deakin depressed patients dopamine dose drugs effects Elevated plus-maze endogenous etal European Journal fenfluramine fluoxetine function gepirone H-imipramine hormone human imipramine imipramine binding increase inhibition Insel Journal of Pharmacology Journal of Psychiatry L6pez-Ibor Linnoila lithium m-CPP major depression MAO inhibitors MAO-A MAO-B mediated melatonin melatonin biosynthesis melatonin synthesis Meltzer metabolism metabolite metergoline migraine milacemide monoamine oxidase Murphy neuroendocrine neurones neurotransmission obsessive-compulsive disorder OCD patients Oxenkrug panic disorder Peroutka Pharmacology pineal melatonin placebo plasma platelet 5-HT platelets post-synaptic prolactin protein Psychiatry Research Psychopharmacology raphe rat pineal re-uptake release ritanserin Sandler serotonergic serotonin receptor serotonin uptake studies suicide symptoms treatment tricyclic antidepressants tryptophan Youdim