ADP-ribosylation of Proteins: Enzymology and Biological Significance
In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions. The development of this field over the past 2 decades reflects very much a modern trend of biological research. As more detailed knowledge accumulates, enigmatic phenomena turn into concepts which create their own enigmata. This process tends to favor the development of multiple, seemingly disconnected, research lines until simplicity emerges from chaos and unifying concepts substitute for controversy. It appears that the field of ADP-ribosylation reactions has not yet attained this latter stage. For example, with the identification of two different classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla tion and poly-ADP-ribosylation reactions, the field split very early into two separate branches of research. With the present volume, we have divided the task of reviewing these two classes of ADP ribosylation accordingly, although their coexistence in eukaryotes may involve a closer functional linkage than hitherto recognized.
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3-aminobenzamide Acad Sci USA acceptor proteins acid Adamietz adenosine adenylate cyclase ADP-ribose ADP-ribose)n ADP-ribosylation ADP-ribosylation of proteins ADP-ribosylation reactions alpha subunit Althaus Berger Berlin Heidelberg binding Biochem Biophys Res Biochemistry Biol Chem Biophys Res Commun Burzio catalyzes cellular cholera toxin chromatin Cleaver differentiation diphthamide diphtheria toxin DNA damage DNA ligase DNA repair effect enzyme erythrocytes FEBS Lett fibroblasts fragment glycohydrolase GTPase guanine guanine nucleotide guanine nucleotide-binding Hayaishi Heidelberg New York Hilz H histone H1 histone H2B hormone human inhibition inhibitors intact cells interaction Katada lymphocytes metabolism mitochondria Miwa modification Moss mouse Natl Acad Sci nicotinamide nuclei nucleotide pertussis toxin phosphodiesterase Poirier poly poly-ADP-ribosylation poly(adenosine diphosphate ribose poly(ADP poly(ADP-ribose poly(ADP-ribose)polymerase polymer polymerase Proc Natl Acad purified rat liver receptors release residues ribosylation role Smulson Springer stimulation strand breaks substrate Sugimura synthetase Tanaka Tanuma thymus tion transducin transferase tumor Ueda Vaughan vitro vivo Wielckens York Tokyo Yoshihara
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