A Biologic Approach to Environmental Assessment and Epidemiology
In this book, Thomas J. Smith and David Kriebel assert that important advances in the quantification of environmental risks can only come through a true synthesis of the fields of environmental epidemiology and exposure assessment. They have built a common biologic model of exposure, physiologic response, and disease, a synthesis of the various existing models which serves to both simplify and improve the application of environmental epidemiology and exposure assessment to current and future environmental chemical risks.
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agent air pollution airways allergen ammonia amount approach arithmetic mean association asthma attack average biological biomarker blood calculated carcinogenic cells Chapter chemical complex confounding contaminants cumulative exposure curve damage define develop diacetyl discrete disease process model dose metric dose-response relationship dosimetric model duration emissions environmental epidemiologic models epidemiologic studies Equation estimate example expo exposed exposure and response exposure assessment exposure data exposure distribution exposure intensity exposure stops exposure-response factors FEV1 Figure function half-time hypotheses important increase individual individual’s inhaled interval investigators irreversible irritation lead levels lung cancer macrophages measure of exposure MeHg metabolism observed occur ozone p-value parameters particles partition coefficient period physiologic population probability produce proportional disease process relationship relative respiratory response result reversible proportional risk routes of entry sampling sensitization silica skin smoking soluble sources subjects symptoms target tissue temporal tion tissue concentration toxic toxicokinetic types values variability variation