A Clinico-Genetic Study of Psychiatric Disorder in Huntington's Chorea
This report presents the findings of a study of people affected by Huntington's chorea and their unaffected relatives, and in particular, of the incidence of functional psychiatric disorder of various types. It also considers the future prospects of the genetics of the condition
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admission affected subjects affected with Huntington's alleles Alzheimer's disease base pairs behaviour and personality behaviour disorder chiatric choreics chromosome clinical cohabiting spouses course of Huntington's dementia depressive illness developing Huntington's chorea Dewhurst disorder in Huntington's disorder occurring DSM-III family members Folstein frequency of functional functional psychiatric disorder functional psychiatric illness genetic linkage HC gene heterozygotes Hunting Huntington's chorea gene Huntington's disease Huntington's gene individuals initial 50 linkage test loci locus major depression male Mean age Medical Genetics mRNA number of affected onset of functional onset of Huntington's Oxford Regional Health patients pedigree personality and behaviour personality disorder polymorphic population predictive test probe proportion protein psychiatric hospital psychiatrically interviewed recombination restriction enzyme RFLP risk for Huntington's schizophrenia shown shows Southern blotting stages subjects affected subjects at 50 subjects at initial subjects with Huntington's survey symptoms syndromes telomere test result ton's chorea total representative sample VNTRs