A Handbook of Mouse Models of Cardiovascular Disease

Front Cover
Qingbo Xu
John Wiley & Sons, Aug 4, 2006 - Science - 402 pages
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The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories.

A Handbook of Mouse Models of Cardiovascular Diseaseáis the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model.

A Handbook of Mouse Models of Cardiovascular Disease:

  • Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis
  • Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure
  • Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems
  • Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapyáand pathophysiology

This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

 

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Contents

1 Mice general information
1
2 Naturally occurring variation among mouse strains
19
3 Transgenic and genetargeted mice in the study of hyperlipidemia
33
the methodology and its application in atherosclerosis research
43
5 Hyperlipidemiainduced atherosclerosis
53
6 Magnetic resonance imaging evaluation of atherosclerotic plaque
67
7 Plaque rupture
79
8 Perivascular cuff electronic and chemical injuryinduced stenosis
89
17 Myocardial ischemiareperfusion
203
18 Cardiac hypertrophy
221
19 The retrogradely perfused isolated heart model
235
20 Measurement of pulse wave velocity
245
21 Gene transfer to dyslipidemic mice
255
22 Hypertension
273
23 Ischemiainduced neovascularisation
287
24 Angiogenesis in biomatrices and artificial materials
299

9 Flowinduced vascular remodeling
103
10 Vein graft atherosclerosis
113
11 Angiotensin IIinduced aortic aneurysms
125
12 Carotidojugular fistula
137
13 Applications to the study of stroke
147
14 Identifying congenital heart defects in embryos using highresolution magnetic resonance imaging
159
heterotopic heart transplantation and aortic interposition grafts
173
16 Heart preconditioning analysis
193
25 Venous thrombosis
311
26 Virusinduced vasculitis
321
27 Surgically induced chronic heart failure
333
28 Cardiac electrophysiology
349
29 Ligation and wire injuryinduced stenosis
363
Index
373
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About the author (2006)

Qingbo Xu. John Parker Professor of Vascular Biology, Department of Cardiac and Vascular Sciences, St George's Hospital Medical School.

Professor Xu has an excellent standing in the field of atherosclerosis with an outstanding scientific track record. He is part of a European Network of Excellence on vascular biology, which is a large consortium of experts. He is an expert in mouse models and in microsurgery. His group pioneers the study of heat shock proteins in atherogenesis and has established the first mouse model of vein graft atherosclerosis, which is proven to be powerful in studying the mechanisms of progenitor cells participating in atherosclerosis. Professor Xu’s group also generated the first PKC knockout mice and analysed protein profiles of cardiovascular cells in these mice.

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