A Handbook of Transcription Factors

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Timothy R. Hughes
Springer Science & Business Media, May 10, 2011 - Medical - 306 pages
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Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution.

This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

 

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Contents

1 Introduction to A Handbook of Transcription Factors
1
2 An Overview of Prokaryotic Transcription Factors
7
3 A Catalogue of Eukaryotic Transcription Factor Types Their Evolutionary Origin and Species Distribution
25
4 Function and Evolution of C2H2 Zinc Finger Arrays
75
5 Homeodomain Subtypes and Functional Diversity
95
Small Molecule Sensors that Coordinate Growth Metabolism and Reproduction
123
7 Methods for Analysis of Transcription Factor DNABinding Specificity In Vitro
155
8 Identification of Transcription FactorDNA Interactions In Vivo
175
9 How Transcription Factors Identify Regulatory Sites in Genomic Sequence
193
10 Transcription Factor Binding Sites and Other Features in Human and Drosophila Proximal Promoters
205
11 Interactions of Transcription Factors with Chromatin
223
12 Transcription Factor Effector Domains
261
13 LargeScale Nuclear Architecture and Transcriptional Control
279
Index
297
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