A Master Regulator of Oxidative StressThe Transcription Factor Nrf2
Jose Antonio Morales-Gonzalez, Ángel Morales-González, Eduardo Osiris Madrigal-Santillan
BoD – Books on Demand, Dec 21, 2016 - Science - 210 pages
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
What people are saying - Write a review
We haven't found any reviews in the usual places.
NRF2 Rewires Cellular Metabolism to Support the Antioxidant
Multiple Modes of Nrf2 Regulation and Transcriptional
FeedForward and FeedBack Circuits of the NRF2AP1
Nrf2 Contributes to the Poor Prognosis
Possible Role of Nrf2 in Oxidative and Inflammatory Processes
The Effect of Nrf2 on Diabetic Complications
An Adaptive Response Pathway
Nrf2 and Parkinsons Disease
Oxidative Stress and Disease
acid activates Nrf2 activation of Nrf2 amyotrophic lateral sclerosis Antioxid Redox Signal antioxidant defense antioxidant response element apoptosis associated autophagy BACH1 bilirubin binding Biochem Biol Chem biological biosynthesis cancer cells Cell Biol cell death cellular curcumin cysteine cytoprotective degradation detoxification diabetic drug dysfunction endogenous enzymes estrogen feed-back circuit feed-forward Free Radic Free Radic Biol function genetic glucose glutathione heme human increased induced inflammation inhibit interaction Keap1 kinase lipid mechanisms mediated menopause metabolism mice mitochondrial modulates Molecular molecules mutations NADPH Natl Acad Sci neurodegenerative neurons neuroprotective NQO1 Nrf2 activation Nrf2 expression Nrf2 pathway NRF2 target Nrf2-ARE pathway NRF2-regulated overexpression oxidative damage oxidative stress Parkinson's disease patients phosphorylation Proc Natl Acad promotes proteasome protects protein reactive oxygen species Redox Signal reductase regulation role of Nrf2 ROS levels signaling pathway stem cells studies superoxide dismutase thioredoxin transcription factor transcription factor Nrf2 translocation tumor ubiquitination upregulation Wang Yamamoto Zhang