A Master Regulator of Oxidative StressThe Transcription Factor Nrf2

Front Cover
Jose Antonio Morales-Gonzalez, Ángel Morales-González, Eduardo Osiris Madrigal-Santillan
BoD – Books on Demand, Dec 21, 2016 - Science - 210 pages
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
 

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Contents

NRF2 Rewires Cellular Metabolism to Support the Antioxidant
21
Multiple Modes of Nrf2 Regulation and Transcriptional
49
FeedForward and FeedBack Circuits of the NRF2AP1
65
Nrf2 Contributes to the Poor Prognosis
93
Possible Role of Nrf2 in Oxidative and Inflammatory Processes
113
The Effect of Nrf2 on Diabetic Complications
131
An Adaptive Response Pathway
145
Nrf2 and Parkinsons Disease
169
Oxidative Stress and Disease
185
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