A Pharmacology Primer: Theory, Application and Methods
This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments.
The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal.
At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer.
*New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance.
*Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member.
*Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles.
*Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Other editions - View all
A Pharmacology Primer: Theory, Applications, and Methods
Terrence P. Kenakin
No preview available - 2006
absorption acetylcholine affinity agonism agonist response allosteric modulator antagonism assay b-adrenoceptor basal binding biological blockade calcitonin receptor calculated carbachol CCR5 cell cellular chemical clearance competitive antagonist compounds concentration of agonist concentration-response curves constitutive activity cyclic AMP ð Þ data points detect displacement dissociation constant dose dose-response curves drug discovery druglike effects efficacy Emax enzyme Equation equiactive equilibrium dissociation constant estimate example experimental full agonist function G-protein given human calcitonin increase inhibition inhibitor insurmountable interaction inverse agonist isoproterenol kinetics ligand linear Log agonist maximal response measure metabolism molecular molecules muscarinic nist observed operational model orthosteric panel parameters partial agonist pharmacokinetics Pharmacol pharmacology potency prenalterol produce protein radioligand ratio receptor activity receptor density receptor occupancy Response ¼ saturation Schild analysis Schild regression screening seen shown in Figure shows slope specific stimulus stimulus-response Table target therapeutic tion tissue values yield