A Pharmacology Primer: Theory, Applications, and Methods
The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.
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Chapter 2 How Different Tissues Process Drug Response
Chapter 3 DrugReceptor Theory
The Measurement of Affinity and Efficacy in Functional Assays
Chapter 6 Orthosteric Drug Antagonism
Chapter 7 Allosteric Drug Antagonism
Chapter 8 The Process of Drug Discovery
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absence activity affinity allosteric allosteric modulator amount analysis antagonism antagonist approach assay binding biological bound calculated cause cell cellular Chapter chemical circles competitive complex concentration conformations considered constant constitutive coupling defined dependent described detect determine discussed displacement dissociation distribution dose dose-response curves drug drug discovery effects efficacy Equation equilibrium error estimate example experimental experiments expression factor Figure full agonist function G-protein given human increasing indicates inhibition interaction lead ligand linear maximal response mean measure mechanism method molecules natural observed obtained operational parameters partial agonist pharmacology plot possible potency presence produce protein radioligand range ratio receptor referred regression relationship relative resulting sample saturation Schild screening seen shift shown shown in Figure shows signal slope specific stimulus structure studies Table therapeutic tion tissue values yield