A Pharmacology Primer: Theory, Applications, and Methods
The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.
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Chapter 2 How Different Tissues Process Drug Response
Chapter 3 DrugReceptor Theory
The Measurement of Affinity and Efficacy in Functional Assays
Chapter 6 Orthosteric Drug Antagonism
Chapter 7 Allosteric Drug Antagonism
Chapter 8 The Process of Drug Discovery
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adsorption affinity agonism agonist concentration agonist response allosteric antagonist allosteric modulator assay basal binding Bmax calcitonin receptor calculated CCR5 cell cellular chemical competitive antagonist concentration of agonist concentration of antagonist concentration-response curves constitutive activity cyclic AMP ð Þ data points defined dissociation constant dose-response curves drug discovery effects efficacy Emax Equation equilibrium dissociation constant estimate example experimental filled circles full agonist function G-protein given histamine human calcitonin increasing inhibition interaction inverse agonist isoproterenol ligand linear Log agonist maximal response measure molecular molecules muscarinic noncompetitive antagonist observed open circles operational model orthosteric parameters partial agonist Pharmacol pharmacology physiological potency prenalterol presence protein quantify radioligand receptor activity receptor density receptor occupancy receptor reserve receptor systems Response ¼ response curve sample saturation Schild analysis Schild regression screening seen shown in Figure signal simple competitive slope specific stimulus stimulus-response therapeutic tissue transfected values yield