A Primate Model for the Study of Colitis and Colonic Carcinoma The Cotton-Top Tamarin (Saguinus oedipus)

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CRC Press, Jul 6, 1993 - Medical - 352 pages
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A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles as a function of disease state, occurrence of extra-intestinal manifestations, and possible causal agents of colitis are also discussed. Prevalence of spontaneous CTT colonic carcinoma is considered from genetic influence, from promotion by colitis, and through the use of diagnostic and prognostic tools such as flow cytometry. Changes in fecal steroids, serum markers, colonic glycoprotein, polyamine metabolism, and immunobiology of CTTs are discussed in regard to disease condition. The book is an essential reference on the CTT model for gastroenterologists, oncologists, and all researchers interested in digestive diseases.
 

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Contents

Roderic B Mast Josť Vicente Rodriguez and Russell A Mittermeier
4
Chapter
8
Natural History of CottonTop Tamarins
15
Conclusions
35
Chapter 2
39
Breeding the CottonTop Tamarin Saguinus oedipus in Captivity
45
Chapter 3
55
Chapter 4
83
Chapter 10
161
Chapter 11
171
Chapter 12
184
Chapter 13
199
Chapter 14
207
Chapter 15
221
Tamarin Colon Cancer and Flow Cytometry
231
Chapter 17
241

A Protocol to Evaluate the Efficacy of Anticolitic Agents Against
84
Chapter 16
99
Chapter 5
101
Chapter 6
113
Chapter 7
127
Neal K Clapp Marsha A Henke Robert M Hansard
133
Chapter 9
145
Chapter 18
253
Chapter 19
267
Chapter 20
283
Chapter 21
295
Chapter 22
309
Chapter 23
319
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