A Primate Model for the Study of Colitis and Colonic Carcinoma The Cotton-Top Tamarin (Saguinus oedipus)
A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles as a function of disease state, occurrence of extra-intestinal manifestations, and possible causal agents of colitis are also discussed. Prevalence of spontaneous CTT colonic carcinoma is considered from genetic influence, from promotion by colitis, and through the use of diagnostic and prognostic tools such as flow cytometry. Changes in fecal steroids, serum markers, colonic glycoprotein, polyamine metabolism, and immunobiology of CTTs are discussed in regard to disease condition. The book is an essential reference on the CTT model for gastroenterologists, oncologists, and all researchers interested in digestive diseases.
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Roderic B Mast Josť Vicente Rodriguez and Russell A Mittermeier
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acute colitis adults animal model antigen associated bile acids biopsies body weight callitrichids captive cecum cells chronic colitis Clapp clinical cohort cohort II colitis and colon colitis in cotton-top Colombia colon cancer colonic carcinoma colonic mucin colonic mucosa colonoscopy colony-born colorectal cancer colorectal carcinoma conservation coronavirus coronavirus-like particles cotton-top tamarin cotton-top tamarins Saguinus crypts CTT colon death diarrhea diet dietary disease epithelium evaluated Figure first-degree relatives forest fuscicollis Gastroenterology gene genetic glycoconjugates glycoproteins grade habitat Henke histological Humason important increased inflammatory intestinal large bowel Lushbaugh malignant marker metastases MHC class monkeys monoclonal antibodies mortality mucin mucosa nutritional Oak Ridge observed ODC activity ORAU pathogenesis patients polyamine polyposis population primate primate species protein reported Saguinus oedipus Saguinus oedipus oedipus serum staining stool condition susceptibility syndrome Table tamarins and marmosets tamarins Saguinus oedipus Tardif tissue tumor ulcerative colitis virus