A Primate Model for the Study of Colitis and Colonic Carcinoma The Cotton-Top Tamarin (Saguinus oedipus)
A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles as a function of disease state, occurrence of extra-intestinal manifestations, and possible causal agents of colitis are also discussed. Prevalence of spontaneous CTT colonic carcinoma is considered from genetic influence, from promotion by colitis, and through the use of diagnostic and prognostic tools such as flow cytometry. Changes in fecal steroids, serum markers, colonic glycoprotein, polyamine metabolism, and immunobiology of CTTs are discussed in regard to disease condition. The book is an essential reference on the CTT model for gastroenterologists, oncologists, and all researchers interested in digestive diseases.
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acute and chronic acute colitis adults animal model antigen associated bile acids biopsies body weight Callithrix jacchus callitrichids captive carcinoembryonic antigen cecum cells chronic colitis Clapp clinical cohort colitis and colon colitis in cotton-top Colombia colon cancer colonic carcinoma colonic mucosa colonoscopy colony-born colorectal cancer common marmoset conservation coronavirus coronavirus-like particles cotton-top tamarins Saguinus crypt CTT colon death diarrhea dietary epithelium evaluated exudates feeding Figure Flurer forest fuscicollis Gastroenterology genetic geoffroyi glycoproteins grade habitat Henke histological human colon Humason important increased infection inflammatory intestinal large bowel Lushbaugh malignant marker MHC class monkeys monoclonal antibodies mucin mucosa nonhuman primates nutritional Oak Ridge observed ODC activity ORAU patients polyamine population primate primate species Primatol protein reported Saguinus oedipus oedipus serum staining stool condition susceptibility syndrome Table tamarins and marmosets tamarins Saguinus oedipus Tardif tissue tumor ulcerative colitis virus