A Textbook of Modern Toxicology
Toxicology is the science of poisons, embracing the physical and chemical study of all the known poisonous substances, as well as the methods of testing for them, their action on the living body, and the postmortem results they occasion. The Third Edition of this benchmark text once again proves the most authoritative resource on the subject for both students and practicing professionals.
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absorption acetaminophen acetylation acid acute agents alcohol animals aromatic behavioral benzo(a)pyrene bile Biochemical blood cancer carbamates carbon carcinogenesis carcinogens catalyzed cause cells cellular chromosomes Chronic Toxicity complex compounds concentration conjugation covalent binding cyanide cytochrome P-450 decrease detoxication dose drugs elimination environmental enzyme epoxide epoxide hydrolase ethanol example excretion exposure factors females Figure formation function gene genetic glucuronide glutathione hepatic hepatotoxicity hexobarbital humans hydrocarbons hydroxylation important increase induce inhibition inhibitors insecticides interaction involved isozymes kidney known levels lipid liver lung mammalian mammals mechanisms membrane metabolites methyl microsomal molecular molecules monooxygenase system mutagenic mutations occur organ organophosphates oxidase oxidation pesticides phase-two poisoning pollutants produce protein rabbit rats reactions reactive intermediate reactive metabolites respiratory result route skin soluble solvent species studies substrate sulfate Teratogenesis teratogenic Teratology tests tion tissue TOXIC ACTION toxic effects toxicity Toxicology transferase tumors usually vitro vivo whereas xenobiotics York zoxazolamine