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MODEL SYSTEMS IN PATHOLOGY
TOXIC AGENTS IN HUMAN PATHOLOGY
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abnormal accumulation acetyl acetyl-CoA action activity agent alkaline phosphatase amino acids anaemia bilirubin biochemical blood brain carbon tetrachloride carcinogenic central nervous system chemical choline chondria chromosomes citrate coenzymes complex compounds concentration condition copper cytochrome oxidase cytoplasm damage defect deficiency degeneration dehydrogenase diet disease effect electrons energy enzyme excreted experimental animals failure fatty acids fluoroacetate folic acid formation fraction function galactose gene genetic glucose glycogen glycolysis haemoglobin histological increase inhibition isolated jaundice kidney known lesions liver liver cells mechanism metabolised metabolism microsomes mitochondria molecule necrosis normal nucleic acids nucleotides nucleus oxidative phosphorylation oxidised oxygen pathology pathway phenylalanine phosphate phospholipid poisoning porphyrins produces protein pyridine pyridine nucleotides pyruvate reaction red cells reduced respiration respiratory result revealed specific structure studies subcellular substrate succinate suggested synthesis thioacetamide tion tissues toxic toxin tricarboxylic acid cycle tryptophane tumours tyrosine urine vitamin vitro