A Decade of HAART: The Development and Global Impact of Highly Active Antiretroviral Therapy, Volume 1
OUP Oxford, Aug 28, 2008 - Medical - 516 pages
Highly active antiretroviral therapy (HAART) is a therapeutic intervention developed by clinicians and researchers in order to fight the HIV pandemic. It has contributed to a significant reduction in AIDS-related mortality and allowed many previously bed-ridden patients to live healthier, more productive lives. Until the advent of HAART in 1996, a diagnosis of HIV infection was considered a death sentence. A decade later, the disease has been transformed into a serious, yet potentially manageable, medical condition for thousands of people living with HIV/AIDS in the developed world - almost overnight creating a generation of "HIV Survivors" - and forged a global movement to ensure that its Lazarus-like benefit reaches millions more in the developing world. This book reviews the achievements of HAART over the past decade, and explores the challenges that may arise in the future. It recounts key landmarks in the development and introduction of HAART from the perspective of clinicians, researchers, economists, sociologists, and public policy experts, including the co-discoverers of HIV, Luc Montagnier and Robert Gallo. It explores the evolution of the disease, the evolution of HIV treatment, and the economic, social, and public policy impacts of both HIV and the introduction of HAART.
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defining milestones on the road to HAART
The outcome and impact of 10 years of HAART
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active antiretroviral therapy adherence adults antiretroviral drugs antiretroviral regimen antiretroviral therapy antiretroviral treatment associated baseline Brazil CD4 count cells/mm centres China Clin clinical co-infection copies/mL death diagnosis didanosine drug resistance efavirenz effects EuroSIDA first-line follow-up genotype global guidelines HAART Haiti health systems healthcare hepatitis highly active antiretroviral HIV disease HIV epidemic HIV RNA HIV treatment HIV-infected patients HIV-NAT HIV-positive HIV/AIDS Hospital human immunodeficiency virus human resources IDUs Immune Defic Syndr impact increased initiation International AIDS Conference JAcquir Immune Defic lamivudine Malawi median monitoring mortality mutations nevirapine NNRTI NRTIs Opportunistic Infections outcomes plasma PLWHA population programme protease public health rates reported response reverse transcriptase inhibitor risk ritonavir RTV-boosted saquinavir scale-up sector sexual South Africa stavudine subtype survival syndrome testing Thailand toxicity transmission trial viral load virologic women Zambia zidovudine