A Non-photochemical Approach to Vitamin D Analogs: Partial Synthesis of (20R) and (20S) 9, 10-seco-1,3,5(10)-cholestatriene-3-o1 ; Approaches Towards the Synthesis of the Left Hand Segment of Antitumor CC-1065 |
Common terms and phrases
¹H NMR 9,10-seco steroid acetone AIBN aldehyde allyl benzene bipyrrole 24 calcium carboxylic acid catalytic Chem chromatography over silica cm¯¹ CO₂Et combined organic extracts compound crystallization derivative diastereomer dried MgSO4 electrophilic eluted ester ether EtO₂C NH EtOAc EtOAc/hexane EtOH Evaporation of solvent extracts were washed flash chromatography gave gravity column heated at reflux hexane hydrolysis imidazole isomer Leusen Lythgoe m/e Calcd methylene NH4Cl nitrile NMR CDC13 outlined in Scheme oxidation phenol proton pyridine pyrrole reagent reduction room temperature samarium saturated NaCl solution Scheme VII Scheme XIX seco steroid side chain silica gel SO2 Ph SO₂Ph sodium chloride solution and dried solvent solvent and flash solvent was evaporated steroid stirred at room Synthesis of Ethyl Tetrahedron Lett TosMIC tricyclic phenol 46 Vitamin D Vitamin D3 washed with saturated xanthate он