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FoghAndersen A Comprehensive Approach
Recent Studies Pertaining to the Inheritance
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abnormal affected child affected parent Aneuploidy appears approximately autosomal dominant births cause cell children with clefts chromosome CL(P cleft lip cleft lip and/or cleft palate cleidocranial dysostosis concordance congenital anomalies CP and CLCP defect dominant gene drome embryo environmental factors environmental teratogens et_aL familial incidence fistulae Fogh-Andersen Fraser and Calnan genes for clefts genetic factors Gorlin and Pindborg incidence figures incidence of clefts individuals with CP inheritance of clefts isolated cleft palate Klippel-Feil syndrome lip and cleft lip and palate lip and/or palate literature Lutz and Moor males manner of inheritance maternal micrognathia mode of inheritance monozygotic twins mutations normal offspring palatal cleft parental age paternal age patients pattern of anomalies pedigrees Pierre Robin syndrome polygenic inheritance population present probands Rank and Thomson recessive regarding relatives result sex ratio sex-modified siblings sibships suggested syndactyly tion trisomy trisomy syndrome twin studies types of clefts Woolf and associates