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ANOVA assessment of average assessment of bioequivalence assessment of population average bioavailability average bioequivalence bioavailability characteristic bioequivalence assessment bioequivalence is concluded bioequivalence step bioequivalence studies Biometrics Biopharmaceutics carryover effects cent confidence interval Chow corresponding covariance matrix crossover study decision rule degrees of freedom Drug Information Journal drug product estimates F distribution Fieller's confidence interval fixed effect formulation effects formulation means formulation variances individual bioequivalence intra-subject correlation intra-subject variabilities Latin square level of significance log-normal model log-transformation logarithmic scale Mann-Whitney tests methods normal model normality assumptions null hypotheses one-sided hypotheses ooo ooo ooo original scale Orion Pharma P-values parametric period Pitman-Morgan's population and individual population bioequivalence random ratio reference formulation rejected REML scale of measurement Schuirmann Statistics in Medicine switchability test and reference test formulation test statistics testing results two-period crossover design two-sequence unequal carryover uniform covariance structure variability of bioavailability variance components versus Vuorinen