A Textbook of Modern Toxicology
This revised edition reflects changes in the core curriculum subjects covered in the basic toxicology course for graduate students. Designed as an introductory textbook, it emphasizes the fundamental basis of toxic action at the cellular and molecular levels and lays the foundation for specialized courses in toxicology. Additional topics include metabolic activation and cellular protection, clinical toxicology diagnosis and treatment, ecosystems, environmental toxicology, ecotoxicology, case histories, and future consideration for environmental and human health.
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ABSORPTION AND DISTRIBUTION
METABOLISM OF TOXICANTS
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absorption acetyl acid activity acute toxicity Aflatoxin agents alcohol animals areas aromatic assessment endpoints benzo(a)pyrene bile binding bioaccumulation blood cancer carbon carcinogenesis carcinogens catalyzed cause cells cellular chemicals complex compounds concentration conjugation contaminants covalent cytochrome P450 detoxication dose drugs ecological elimination environment environmental enzyme epoxide ethanol example excretion exposure factors formation function gene glucuronide glutathione hexobarbital human hydrocarbons hydrolysis important increase induced inhibition inhibitors insecticides interactions involved isozymes kidney known levels lipid lipophilic liver lung mammals mechanisms membrane mercury metabolism metabolites metals methyl microsomal models molecular molecules monooxygenase nervous system occur organic oxidation pesticides poisoning pollutants potential processes protein rats reactions reactive intermediates reactive metabolites reduced respiratory result risk assessment route skin solubility solvent species stressors studies substrates sulfate teratogenic tion tissue toxic effects toxicity toxicity testing Toxicol toxicology toxins transport tumor types usually vivo whereas xenobiotics