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Montes de Oca Luna R 1 Wagner D S 2 McMasters K M 1 Pena
Jian Y SchmidtGrimminger D C Broker T R Chow L T Dept
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adenovirus allele amino analysis antibodies apoptosis apoptotic assay Biology BRCA1 c-myc Cancer Center Cancer Institute Cancer Research carcinoma CDK4 cDNA cell cycle arrest cell death cell lines cellular chromosome clones complex cyclin cyclin-dependent kinases demonstrated Dept detected differentiation DNA binding DNA damage domain encodes exon expression fibroblasts function genomic growth arrest homologous homozygous Hospital human identified IGF2 inactivation induced inhibition inhibitor interaction involved kinase activity Laboratory levels lung markers MDM2 mechanism mediated melanoma Microbiology mouse mRNA murine mutations normal Northern blot novel nuclear oncogene Oncology overexpression p53 protein Pathology pathway patients phase phenotype phosphorylation proliferation promoter receptor region regulation response retinoblastoma retinoblastoma protein role School of Medicine sequence signaling specific suppression target telomerase tissue transactivation transcription factors transcriptional activation transfected transformation transgenic transgenic mice tumor cells tumor suppressor gene tumorigenesis tyrosine University vitro vivo wild type wild-type p53