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Laboratory of Molecular Biology National Cancer lnstitute yVrun uin
1 Leroy P 1 Grave L 1 Spehner D 2 Santis G 3
E Wagner Vienna University Biocenter Austria
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adenoviral vector adenovirus adenovirus fiber amino amphotropic angioblasts antigen assays baculovirus binding cancer cells capsid cationic cell lines cell surface cell types cell-specific cellular receptor chimeric envelop chimeric fiber complexes conjugates constructs containing culture demonstrated developed ecotropic efficiency endogenous endosome endothelial cells envelope protein factor VIII FGF2 fiber protein fibroblasts folate function fusion protein gene delivery gene expression gene therapy gene transfer genetic glycoprotein hematopoietic hepatocytes HepG2 high affinity immunotoxins incorporated infection insertion integrins interaction Laboratory ligand linker lipids liposomes lnstitute luciferase mediated melanoma membrane mice modified Molecular molecules murine muscle mutant novel overexpressed particles peptide plasmid polyK polylysine polypeptide promoter pseudotyped virus receptor receptor-mediated recombinant reporter gene retroviral vectors scFv School of Medicine selected sequences single chain specific target cells TARGETED GENE therapeutic gene tissue-specific tissues TNFa toxin transduced transfection transgene transgene expression tropism tumor cells University uwunn viral virions viruses vitro VSV-G