Written by a leading expert on Aspirin-related research, this is the first comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever.
The text is written with a wide audience in mind and to be readily understandable for clinicians as well as biomedical researchers and pharmacologists alike. The content is up to date and includes the latest results of clinical and academic research, with a balanced view on the disputed properties of this famous drug.
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acetaminophen acetylation acetylsalicylic acid actions of aspirin acute American Journal analgesic anti-inflammatory antiplatelet antiplatelet drugs antipyretic antithrombotic apoptosis arachidonic acid aspirin aspirin and salicylate aspirin intake aspirin resistance aspirin treatment aspirin-induced associated asthma atherosclerosis biosynthesis bleeding blood cardiovascular cells Circulation clopidogrel colorectal cancer compound coronary artery coxibs cyclooxygenase dipyridamole drugs effects of aspirin efficacy end point endothelial England Journal enzyme factors gastric gene increased inflammatory inhibition of platelet inhibitors injury interaction Journal of Clinical Journal of Medicine Kawasaki disease Lancet liver long-term low-dose aspirin Medical metabolism metabolites mg/day mucosal myocardial infarction NSAIDs ofaspirin oral oxidative pain patients PGE2 Pharmacology placebo platelet platelet activation platelet aggregation platelet function preeclampsia pregnancy primary prevention prostacyclin prostaglandin protein randomized trials receptor reduced renal Reye s syndrome risk salicylic acid Section side effects significant therapeutic therapy thrombin Thrombosis thromboxane formation tion tissue toxic traditional NSAIDs vascular versus vitro vivo