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HISTORICAL S A Waksman 1
TIIE CIIEMIsTRY oF AcTINoMYcIN A W johnson
BIOGENESIS OF THE ACTINOMYCINS E Katz
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actino actinomycin activity agent Alloisoleucine amino acid animals antibiotic antibioticus antibody antibody synthesis antigen Biochem Biol Biophys biosynthesis Brockmann Cancer carcinoma cells cellular chemical chemotherapy chick chlorambucil choriocarcinoma chromophore clinical concentrations culture D-valine differentiation DMBA dose of actinomycin double-stranded drug effects of actinomycin enzyme Exptl ﬁndings ﬁrst ﬁve formation formed gene action growth Hackmann hydroxyproline immune immunological incorporation infection inﬂuence inﬂuenza inhibition inhibitors intravenous isolated Katz L-Meval L-Meval L-Thr liver messenger RNA metabolic metastases methotrexate mice molecule Mouse mRNA mycin N-Methylvaline N.Y. Acad Natl normal nucleic acid observed organism patients peptide pg/ml phenoxazinone precursor Proc produced proline protein synthesis puromycin rats reaction Reich replication response ribonucleic acid RNA synthesis Rous sarcoma Rous sarcoma virus Sar Sar Sar sarcosine Sarcosine Sarcosine Schmidt-Kastner sensitive signiﬁcant speciﬁc spleen Streptomyces studies therapy tion tissue titer toxicity treatment tryptophan tumor Valine viral RNA Virology virus viruses vitro Waksman Wilms