Actions of Progesterone on the Brain
D. Ganten, D. Pfaff
Springer Berlin Heidelberg, Aug 1, 1985 - Medical - 216 pages
It is well established that progesterone plays a role in the brain and hypophysis as a facilitator and inhibitor of sexual behavior and gonadotropin release in the female rat (Everett 1961; Caligaris et al. 1971; Brown-Grant and Naftolin 1972; Dorner 1972; Meyerson 1972; Barraclough 1973; Goldman and Zarrow 1973; Mann and Barraclough 1973; Freeman et al. 1976; Feder and Marrone 1977; Goodman 1978; Attardi 1981), guinea pig (Morin and Feder 1974), and primates (Odell and Swerdloff 1968; Spies and Niswender 1972; Yamaji et al. 1972; Karsch et al. 1973; Dierschke et al. 1973; Knobi11974; Clifton et al. 1975). In an attempt to learn whether a specific progesterone uptake mechanism exists in the brain and the hypophysis, the distribution and retention pattern of radioactivity after in vivo injection of labeled progesterone was studied. Early work of Kato (1963) did not show a selective uptake of radioactivity in the hypo thalamus of immature and estrogen-primed immature rats after injection oflow specific-activity [14C]progesterone, but some tendency of the reticular formation to take up radiation was observed. Laumas and Farooq (1966) reported that after intravenous administration of labeled progesterone to ovariectomized estrogen treated rats, radioactivity in the brain and pituitary appeared to show a very slight, insignificant increase 1-2 min after injection, but the uptake pattern was not definite, as had been seen with estradiol. Seiki et al.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Test Models for Antigestagens
8 other sections not shown
Other editions - View all
action activity administration amygdala androgen antiprogestins binding sites Biochem Blaustein and Feder brain and hypophysis Brain Res cerebral cortex concentration corpus luteum Correlations cyclic cytosolic progestin receptors domperidone doses E2 treatment effects of progesterone Endocrinol Endocrinology estradiol estrogen receptors estrogen treatment estrogen-inducible estrogen-primed estrous cycle exogenous facilitation Feder HH female rats feminine reproductive behavior gonadotropin Gorski guinea pig Horm Behav HPOA hypophysis implants increase induction of sexual inhibition inhibitor injection lordosis behavior MacLusky and McEwen male rats MBH-POA medial menstrual cycle neonatal Neuroendocrinology neurons nuclear progestin receptors Onouchi ovarian ovariectomized rats OVX rats Parsons Pfaff DW physiological pituitary plasma postnatal pregnancy premenstrual preoptic area proceptive proges progesterone receptor progestin binding progestin receptor levels protein synthesis rat brain Raynaud response rhesus monkey Sakuma secretion serum sex difference sexual behavior sexual receptivity Södersten specific steroid hormones stimulation studies terone tion uterine uterus