Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management

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Laurence Klotz
Springer Science & Business Media, Jun 21, 2012 - Medical - 208 pages
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Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.
 

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Contents

The Problem of Cancer Overdiagnosis and Overtreatment
1
Patient Selection for Active Surveillance
9
Predicting HighRisk Disease Using Tissue Biomarkers
22
Predicting HighRisk Disease Using Serum and DNA Biomarkers
35
Triggers for Intervention in Men on Surveillance
55
The Role of MRI in Active Surveillance
66
Active Surveillance The European Experience
81
Active Surveillance The Canadian Experience
95
Interpreting PSA Kinetics Using GLMM Technique
130
The Potential Bene fi ts of Diet and Physical Activity Among Active Surveillance Patients with LowBurden Prostate Cancer
139
The Role of 5 a Reductase Inhibitors 5ARIs in Expectant Management of LowRisk Prostate Cancer
153
Urologists Opinion on Active Surveillance USA Versus the Netherlands
157
Clinical Pearls in Managing Patients on Surveillance
169
Active Surveillance Focal Therapy and the Future
173
The Economics of Active Surveillance for Prostate Cancer
179
The Future of Active Surveillance
186

Psychosocial Aspects of AS
106
Statistical Considerations for Patient Selection and Triggers for Intervention in Active Surveillance
121

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