Acute Blood Purification
Hiromichi Suzuki, Hiroyuki Hirasawa
Karger Medical and Scientific Publishers, Jan 1, 2010 - Medical - 195 pages
Acute organ damage and the ensuing multiple organ failure are the result of a pathophysiological process involving various cytokines. Once activated, these proteins cannot be eliminated even when the kidneys function at their maximum capacity. To counteract this mechanism, researchers in Japan have developed an innovative concept employing blood purification to remove the overwhelming cytokines. This book describes the use of hemodiafiltration to inhibit the cytokine storms which cause serious organ damage in patients with septic shock. Moreover, the technical construction of the blood purification system, which includes various machines, devices, membranes, fluids, etc., is explained in detail. Finally, leading experts discuss the concept of continuous renal replacement therapy as the standard care in critically ill patients with severe acute kidney injury. Describing the current state of acute blood purification, this publication provides new impulses and opens new avenues in the treatment of acute organ damage.
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Acute Blood Purification acute kidney injury acute pancreatitis acute renal failure adsorbing adsorption albumin anticoagulant APACHE II Artif Organs Basel Bellomo blood flow rate blood IL-6 level blood levels cardiac circuit clinical continuous hemodiafiltration continuous hemofiltration continuous renal replacement Contrib Nephrol creatinine Crit critically ill patients CRRT cytokine removal cytokine-adsorbing dialysis direct hemoperfusion dose effects efficacy endotoxin extracorporeal filtration fluid hemodialysis hemodynamic hemofiltration hemoperfusion heparin hepatic failure HFCHDF humoral mediators hypercytokinemia improved Japan Karger Matsuda membrane hemofilter ml/h ml/min modality mortality nafamostat mesilate Nakamura non-renal indications online CHDF patients with acute patients with septic patients with severe pediatric patients pg/ml plasma exchange plasmapheresis PMMA PMX-DHP PMX-F polymyxin pressure protein Purification in Critical renal replacement therapy Ronco sepsis septic shock severe sepsis Shiga H SOFA score substances surgery survival rate syndrome Ther Apher tion treated treatment ultrafiltration