Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 9
National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
National Academies Press, Sep 30, 2009 - Nature - 462 pages
This book is the ninth volume in the series Acute Exposure Guideline Levels for Selected Airborne Chemicals, and reviews AEGLs for bromine, ethylene oxide, furan, hydrogen sulfide, propylene oxide, and xylenes.
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4 Hydrogen Sulfide
5 Propylene Oxide
Addressing the Use of PBPK Models to Support Derivation of Acute Exposure Guideline Levels1
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Acute Exposure Guideline adducts AEGL values AEGL-3 values animals blood body weight bromine calculated carcinogenicity cells chamber chemical chlorine clinical signs days/week death decreased derived dyspnea end point ethylene oxide evaluated expo exposed to ethylene exposed to propylene exposure concentration Exposure Guideline Levels extrapolation eye irritation female furan gas chromatography h 4 h h 8 h h/day hemoglobin Henschler 1967 hepatotoxicity human data hydrogen sulfide increased inhalation exposure interspecies isomers Jacobson LC50 values liver lung m-xylene male metabolism mixed xylenes mortality mouse nasal National Research Council NPSH NRC National Research observed odor detection threshold odor threshold parameters partition coefficient PBPK model pharmacokinetic Pharmacol ppm-h propylene oxide propylene oxide vapor rats exposed rats were exposed reported respiratory tract risk assessment Savolainen species Table tion tissue toluene total uncertainty factor toxicity Toxicol Toxicology U.S. Environmental Protection workers xylene xylene exposure