Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 12
Committee on Acute Exposure Guideline Levels, Committee on Toxicology, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council
National Academies Press, May 8, 2012 - Medical - 315 pages
Extremely hazardous substances (EHSs) can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists.
Using the 1993 and 2001 NRC guidelines reports, the National Advisory Committee - consisting of members from the Environmental Protection Agency, the Department of Defense, the Department of Energy, the Department of Transportation, other federal and state governments, the chemical industry, academia, and other organizations form the private sector has developed Acute Exposure Guideline Levels (AEGL) for more than 270 EHSs.
In 1998, the EPA and DOD requested that the NRC independently reviewed the AEGLs developed by the NAC. In response to that request, the NRC organized within its Committee on Toxicology the Committee on Acute Exposure Guideline Levels, which prepared this report, Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 12. This report explains the scientifically valid conclusions that are based on the data reviewed by NAC and consistent with the NRC guideline reports and provides comments and recommendations for how AEGL could be improved.
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National Research Council Committee Review of Acute Exposure Guideline Levels of Selected Airborne Chemicals
5 Methyl Bromide
6 Methyl Chloride
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ACGIH Acute Exposure Guideline AEGL values AEGL-2 values airborne concentration anesthesia Animal Data ATSDR B6C3F1 mice blood body weight brain butane carcinogenicity cardiac sensitization Chemical Company 1952 chloroacetaldehyde chlorobenzene chloroform clinical signs Data Relevant deaths decreased Derivation dogs Dow Chemical Company end point exposed to chloroform exposure duration Exposure Guideline Levels exposure to methyl female genotoxicity gestation days guinea pigs h/day hazard of explosion hepatotoxicity human data IDLH ifosfamide increased interspecies intraspecies kidneys lesions lethality Levels for Hazardous liver lower explosive limit male metabolism metabolites methyl bromide methyl chloride mice mice exposed mortality mouse narcosis National Research Council nephrotoxicity neurotoxicity NIOSH NOAEL Nonlethal NRC National Research observed Occupational Safety odor olfactory epithelium Pharmacol ppm-min ppma propane rabbits rats exposed reported Safety and Health species Summary symptoms threshold tion tissue Total uncertainty factor toxicity Toxicol Toxicology U.S. Environmental Protection uptake