Acute Leukemias V: Experimental Approaches and Management of Refractory Disease
This is the fifth volume in a series on methods of treating acute leukemia. Chemo-resistance is discussed, along with the preclinical evaluation of candidate drugs, the biology and clinical trials in resistant and relapsed disease, and the bone marrow and blood stem cell transplantation. There are also comprehensive sections dealing with growth factors, induction of differentiation immunotherapy and gene therapy. The book thus provides the clinician with guidelines for the use in everyday's practice.
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A New Approach
Fludarabine and AraC Combination for Treatment of Adult Acute
Differential Effect of GMCSF on the Intracellular AraC Metabolism
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ABMT activity acute leukemia acute lymphoblastic leukemia acute myelogenous leukemia acute myeloid leukemia adult allogeneic allogeneic bone marrow AML patients analysis antigens apoptosis Approaches and Management Ara-C ara-CTP assay autologous autologous bone marrow Berlin Heidelberg 1996 blast cells bone marrow transplantation Cancer cell lines chemotherapy chromosome clinical clonal clones complete remission cycles cytarabine cytogenetic cytokines cytotoxic daunorubicin detection diagnosis differentiation donor drug effects etoposide Experimental Approaches expression fludarabine gene GM-CSF granulocyte growth factors Haematol Hematology hematopoietic high-dose human idarubicin induction therapy infusion inhibition interleukin-2 Leukemias V Experimental leukemic cells lymphocytes lymphoma Management of Refractory median mg/m mitoxantrone months normal Oncology P-gp patients with acute patients with AML peripheral blood pharmacokinetic prognostic protein protocol receptor Refractory Diseases Hiddemann regimen relapse response Springer-Verlag Berlin Heidelberg stem cells survival Table tion toxicity translocation treated treatment tumor vitro vivo