Acute Liver Failure

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Cambridge University Press, 1997 - Health & Fitness - 305 pages
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Acute liver failure (ALF), or fulminant hepatic failure, is a distinct clinical syndrome that crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention. With the advent of transplantation, the importance of understanding management of ALF has taken on a new urgency. In this first volume dedicated to ALF, the editors bring together a distinguished team of contributors to describe the etiology, pathology and treatment of this important syndrome. Also covered are consensus techniques in liver transplantation for ALF patients, as well as descriptions of artificial and bioartificial liver assist devices. A section on future treatments includes hepatocyte transplantation, auxiliary grafts and other temporary liver support. Notable for the high level of the authors' expertise, this comprehensive volume should prove invaluable.
 

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Contents

Part One Clinical Syndrome and Etiology
1
Acetaminopheninduced acute liver failure
32
Unusual causes of acute liver failure
43
Pediatricaspects of acute liver failure
53
Part Two Mechanisms of Disease and Multisystem Involvement
67
Pathology of acute liver failure
79
Hepatocyte replication and liver regeneration
93
Part Three Intensive Care Management
115
Part Four Transplantation
173
the American experience
201
Auxiliary liver transplantation
211
Part Five Artificial and Bioartificial Liver Devices
223
Hepatocyte culture and bioreactor design for liversupport systems
245
Clinical experience with an extracorporeal liver assist device
255
Part Six Other Applications
267
Hepatocyte transplantation in liver failure and inherited
285

Brain edema and intracranial hypertension in acute liver failure
144
Management of infection in acute liver failure
158

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Page 252 - Yarmush, ML, Koebe, HG, and Tompkins, RG (1989) Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration.

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