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abdominal activity acute pain administered morphine administered opioids afferent agents analgesic Anesth Analg anesthesia Anesthesiology anesthetic assessment associated blockade blood bolus Brain Res bupivacaine caudal cesarean section chronic pain clinical continuous infusion decrease delivery dorsal horn dose drug dural duration efficacy epidural analgesia epidural infusion epidural morphine epidurally administered evaluation fentanyl hydromorphone incidence increased inhibition injection intramuscular intrathecal intravenous ketorolac lidocaine lumbar mediated meperidine methadone mg/kg monitoring morphine muscle nalbuphine naloxone needle nerve block neurons nociceptive nursing onset opiates opioid analgesia opioid analgesics oral pain control pain management pain relief pain service parenteral patient-controlled analgesia patients receiving pediatric peripheral pharmacokinetics phine plasma concentrations plexus postoperative analgesia postoperative pain postsurgical procedures pruritus receptors renal respiratory depression response sedation sickle cell side effects significant spinal cord spinal opioid stimulation sufentanil surgery surgical technique therapy thoracic tients tion toxicity treatment