Acute and Chronic Liver Diseases: Molecular Biology and Clinics
Springer, Jun 30, 1996 - Medical - 396 pages
The advent of molecular biology and recombinant DNA technology has profoundly changed contemporary medicine. These new scientific tools have made it possible to identify and understand pathological mechanisms at cellular, subcellular and molecular levels which has added previously unimaginable novel dimensions to the diagnosis, therapy and prevention of a rapidly increasing number of diseases of the liver and biliary system. The title of this book - Acute and Chronic Liver Diseases: Molecular Biology and Clinics - expresses this epochal progress in hepatology.
A series of acute or chronic diseases of the liver has been chosen whose modern clinical management most eloquently reflects the impact of the new scientific insight gained from molecular biology. The book, the proceedings of the 87th Falk Symposium (X International Congress of Liver Diseases: Part II of the Basel Liver Week 1995) held in Basel, Switzerland, October 19-21, 1995, first presents an overview of the molecular pathology of the chosen disease, followed by discussions of the clinical inference which this new scientific information entails for diagnosis, management and therapy. This approach is expected to ease the readers' endeavour to connect basic to clinical science and to facilitate appreciation of the enormous progress but also the inherent limitations and arising questions which modern molecular biology has brought to clinical medicine.
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Hepatitis B viral variants
The natural history of chronic viral hepatitis type B and D
epidemiology and clinical course
18 other sections not shown
Acad Sci USA al-antitrypsin alcoholic hepatitis alcoholic liver antibodies antigen apoptosis apoptotic assays associated autoantibodies autoimmune hepatitis azathioprine bile acids bile duct biochemical Biol biopsy cancer cell death cellular cholestasis chronic active hepatitis chronic hepatitis Clin Invest clinical cloning copper cytochrome P450 detected diagnosis dose drug effect enzyme ethanol fibrosis fulminant hepatic failure function Gastroenterology gene genetic genome genotypes haemochromatosis HBs.Ag HCV infection HCV RNA hepatitis C virus hepatocellular carcinoma hepatocytes Hepatol Hepatology hepatotoxicity histological human immune increased induced inhibition interferon lesions levels Lieber liver disease liver failure liver injury liver transplantation markers mechanisms membrane metabolism metabolites molecular mRNA mutations Natl Acad Sci necrosis normal pathogenesis plasma porphyria primary biliary cirrhosis Proc Natl Acad protein rat liver receptor region replication resection response role sequence serum studies survival synthesis therapy tissue toxicity treatment tumour UDCA variant viral hepatitis Virol viruses Wilson's disease