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Acute Toxicity Testing Purpose
Implications for Risk Assessment
In Vitro Cytotoxicity Assays as Potential Alternatives to
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50 test acute toxicity studies acute toxicity testing Alternative Approaches Alternative Methods Animal Testing Ann Liebert Inc antidote approximately assessment ATPase biological calculated chemical agents chemical substances classical LD50 test compounds concentration correlation coefficient cyclophosphamide cytotoxicity cytotoxicity test DDT and Dieldrin dermal Dieldrin discussion dosage level Draize test Drosophila drug endpoints Environmental enzyme estimate ethanol evaluation experimental experiments exposure factors females hazard Health human indicated industrial inhibition irritation L-cysteine LD^q LD50 values LD5Q males Manufacturer Mary Ann Liebert Mean SD median lethal dose metabolism metals Methods in Toxicology methylmercury Mg ATPase mouse number of animals number of dosage Oak Ridge oral studies organochlorides pesticide Ph.D pharmacology Phase potential probit procedure production prostaglandin prostanoid protocols question Rabbit regulatory agencies Research Riboflavin Safety scientific Slide small numbers species statistically Table toxicity data Toxicol Toxicology Volume uridine uridine uptake vaginal tissue vivo York Zbinden