Adaptive Protection of the Heart

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CRC Press, Nov 21, 1990 - Medical - 312 pages
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This book explores the possibilities of protecting the heart against stress and ischemia through adaptation to intermittent hypoxia or to mild, nondamaging stress exposure. These possibilities are based on studies that show an increase in the potency and efficiency of stress-limiting systems when subjected to repeated stress actions, adaptation to high altitude hypoxia, or adaptation to increased physical loads. Any stress reaction is coupled with an activation of central and local stress-limiting systems, such as GABA-ergic, opioidergic, and serotonergic systems in the brain, as well as antioxidants, prostaglandins, and adenosine in executory organs. The book also presents the use of metabolites of stress-limiting systems rather than adaptation as a means to prevent cardiac arrythmias. It also discusses genetically determined deficiencies of stress-limiting systems and their role in the etiology of stress-induced diseases. Cardiologists and researchers studying stress and its effect on cardiovascular systems will find this book extremely useful.
 

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Contents

Conversion of the Cardiotropic Adaptive Effect of Stress into
4
Stress Damages to the Cardiac Function
18
Stress Damages to Energy Provision in Cardiac Muscle
28
Myocardial DNA Injury and Outburst of its Reparative Synthesis
37
Activated Lipid Peroxidation and Cardiomyocyte Membrane Injury
50
Stress Damages to Cardiac Structures
58
The Pathogenetic Chain of Cardiac Stress Damage
64
References
70
References
151
Central StressLimiting Systems and Cardioprotective Effects of Their Mediators
155
Opioidergic System
164
References
179
Chapter 5
185
Prostaglandin System and Heart Protection from Stress and Ischemic
209
References
218
Chapter 6
225

The Place of Primary Cardiac Stress Damage in the Pathogenesis
77
Role of Primary Stress Damage in Arrhythmias and Sudden Cardiac
87
Role of Stress Reaction in Ischemic Disease
96
Relation Between Stress Reaction and Ischemia in the Pathogenesis
112
References
119
Chapter 3
127
Chapter 4
135
Adaptation to Stress Prevents and Abolishes Disturbances to Cardiac
138
Effect of Adaptation to Stress on the Function of the Sarcoplasmic
238
References
245
Adaptation to Hypoxia Prevents Myocardial Stress and Ischemic
252
Adaptation to Intermittent Hypoxia Prevents Hepatic Stress Damage
259
Effect of Adaptation to Intermittent Hypoxia on Tolerance
266
Effect of Adaptation to Intermittent Hypoxia on the Course
269
Chapter 8
283
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