Adenovirus DNA: The Viral Genome and Its Expression

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Springer Science & Business Media, 1986 - Medical - 458 pages
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Although adenoviruses have been established for quite some time as one of the most pliable tools to study the molecular biology of mammalian cells, rapid progress continues to be made with this virus system. The adenoviral genome introduced into the nucleus of cells as a Trojan Horse, as it were, is now facili­ tating investigators to uncover details of cellular mechanisms. In this volume twelve chapters have been collected that summarize important current research on different mechanisms in adenovirus­ infected and -transformed cells. It has become increasingly apparent that some of these mechanisms do not only pertain to highly specialized strategies of the viral genome and its expres­ sion or replication, but may simultaneously shed light on events indigenous to the cell. "Adenovirus DNA: The Viral Genome and its Expression" high­ lights the first publication of the entire annotated sequence of 35. 937 nucleotide pairs of adenovirus type 2 DNA by the Cold Spring Harbor and Uppsala groups (chapter 1). Goran Akusjarvi, Ulf Pettersson (Uppsala University) and Rich Roberts (Cold Spring Harbor) present a survey on the structure and function of the adenovirus-2 genome (chapter 2). A considerable amount of in­ formation has been collected on the biochemical mechanisms in­ vol ved in adenov irus DNA repl ication in human cells. Al though highly specialized in the way of initiating DNA replication, adenov irus DNA repl ication represents probably one of the best studied systems in work on eukaryotic DNA replication.
 

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Contents

A CONSENSUS SEQUENCE FOR THE ADENOV1RUS2 GENOME
xv
STRUCTURE AND FUNCTION OF THE ADENOVIRUS2 GENOME
53
ON THE MECHANISM OF ADENOVIRUS DNA REPLICATION
97
TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF ADENOVIRUS GENE EXPRESSION
129
GENETIC ELEMENTS GOVERNING ADENOVIRAL GENE EXPRESSION
161
INACTIVAT10N OF VIRAL PROMOTERS BY IN VITRO METHYLATION STUDIES ON THE ADENOVIRUS AND BACULOVIRUS SYSTEM
193
EARLY PROTEINS CODED BY THE ADENOVIRUS GENOME FUNCTIONAL ASPECTS
223
ADENOVIRUS GENETICS
247
ALTERATIONS IN CELLULAR FUNCTIONS IN ADENOVIRUS INFECTED AND TRANSFORMED CELLS
311
EXPRESSION OF CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS IN ADENOVIRUSTRANSFORMED CELLS
343
ONCOGENIC TRANSFORMATION BY HUMAN ADENOVIRUSES AND THEIR DNA
367
CLASSIFICATION AND EPIDEMIOLOGY OF ADENOVIRUSES
409
INDEX
443
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