Adenovirus DNA: The Viral Genome and Its ExpressionWalter Doerfler Although adenoviruses have been established for quite some time as one of the most pliable tools to study the molecular biology of mammalian cells, rapid progress continues to be made with this virus system. The adenoviral genome introduced into the nucleus of cells as a Trojan Horse, as it were, is now facili tating investigators to uncover details of cellular mechanisms. In this volume twelve chapters have been collected that summarize important current research on different mechanisms in adenovirus infected and -transformed cells. It has become increasingly apparent that some of these mechanisms do not only pertain to highly specialized strategies of the viral genome and its expres sion or replication, but may simultaneously shed light on events indigenous to the cell. "Adenovirus DNA: The Viral Genome and its Expression" high lights the first publication of the entire annotated sequence of 35. 937 nucleotide pairs of adenovirus type 2 DNA by the Cold Spring Harbor and Uppsala groups (chapter 1). Goran Akusjarvi, Ulf Pettersson (Uppsala University) and Rich Roberts (Cold Spring Harbor) present a survey on the structure and function of the adenovirus-2 genome (chapter 2). A considerable amount of in formation has been collected on the biochemical mechanisms in vol ved in adenov irus DNA repl ication in human cells. Al though highly specialized in the way of initiating DNA replication, adenov irus DNA repl ication represents probably one of the best studied systems in work on eukaryotic DNA replication. |
Contents
A CONSENSUS SEQUENCE FOR THE ADENOV1RUS2 GENOME | 1 |
STRUCTURE AND FUNCTION OF THE ADENOVIRUS2 GENOME | 53 |
ON THE MECHANISM OF ADENOVIRUS DNA REPLICATION | 97 |
TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF ADENOVIRUS GENE EXPRESSION | 129 |
GENETIC ELEMENTS GOVERNING ADENOVIRAL GENE EXPRESSION | 161 |
INACTIVAT10N OF VIRAL PROMOTERS BY IN VITRO METHYLATION STUDIES ON THE ADENOVIRUS AND BACULOVIRUS SYSTEM | 193 |
EARLY PROTEINS CODED BY THE ADENOVIRUS GENOME FUNCTIONAL ASPECTS | 223 |
ADENOVIRUS GENETICS | 247 |
ALTERATIONS IN CELLULAR FUNCTIONS IN ADENOVIRUS INFECTED AND TRANSFORMED CELLS | 311 |
EXPRESSION OF CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS IN ADENOVIRUSTRANSFORMED CELLS | 343 |
ONCOGENIC TRANSFORMATION BY HUMAN ADENOVIRUSES AND THEIR DNA | 367 |
CLASSIFICATION AND EPIDEMIOLOGY OF ADENOVIRUSES | 409 |
| 443 | |
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13S mRNA 1st AUG Acad ACCEPTOR splice Acids Res activity adenovirus gene adenovirus infection adenovirus type Akusjärvi antigen Biol cell lines cells infected cells transformed cellular genes class I MHC Cold Spring Harbor cytoplasm defective deletion DNA binding protein DNA methylation DNA polymerase DNA replication DNA synthesis Doerfler DONOR splice E1A gene early gene early region encoded fragments function gene expression gene products genetic genome hamster host inactivation induce infected cells inhibition initiation intron map units molecular weight mRNA mRNA species mutants N-terminal Natl Nevins nuclear factor nucleotide oncogenic Pettersson phenotype Philipson plasmid poly(A polyadenylation polypeptide Proc promoter protein precursor rat cells reading frame serotypes Shenk specific Spring Harbor Symp terminal protein precursor Terminator UAA transcription unit transfection transformed cells translation tumor tumorigenic type 12 upstream VA-RNAI viral DNA viral genes Virol Virology virus viruses vitro wild-type