Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease
Tony J C Harris
Springer Science & Business Media, Jun 7, 2012 - Medical - 434 pages
Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins interact to assemble AJs and mediate adhesion?
• How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
• How do AJs affect cell behaviour and multicellular development?
• How can abnormal AJ activity lead to disease?
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Acad Sci U S A actin actin cytoskeleton activation adherens junctions afadin apical B-catenin beta-catenin binding Biol Chem cadherin adhesion cadherin endocytosis cadherin—catenin cancer carcinoma catenin cell adhesion molecule cell migration cell polarity Cell Sci cell-cell adhesion cellular classical cadherins clusters complex contacts cytoplasmic cytoskeleton desmosomes Dev Biol differentiation dimers Drosophila dynamics E-cadherin E-cadherin expression ectoderm elegans embryo endocytosis endothelial epidermal epithelial cells epithelium et a1 extracellular F-actin filaments formation gastrulation gene growth factor GTPases herin homophilic inhibition integrin interactions intercellular Kemler kinase mechanism mediates membrane mesoderm metastasis mice microtubule Mol Biol Mol Cell Biol molecular morphogenesis mouse mutations Nat Cell Biol Natl Acad Sci nectin-3 nectins oi-catenin p120 catenin phosphorylation plakoglobin Pokutta Proc Natl Acad promotes proteins receptor region regulation role signaling pathways stem cells strand-swap structure Takai Takeichi tight junctions tion tissue transcription Troyanovsky tumor vinculin Wnt signaling X-dimer Xenopus