Adhesion Molecules: Function and Inhibition

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Klaus Ley
Springer Science & Business Media, Oct 27, 2007 - Medical - 309 pages
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Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided.

The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.

 

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Contents

Rodger P McEver
3
Pselectin glycoprotein ligand1 PSGL1 3
21
Bullard
71
Auerbach Lin Yang and Francis W Luscinskas
99
Britta Engelhardt
117
Sharon J Hyduk and Myron I Cybulsky
141
Alan R Schenkel and Minsoo
175
William A Muller
201
MathieuBenoit Voisin and Sussan Nourshargh
221
Marko Salmi and Sirpa Jalkanen
237
Stefan Butz and Dietmar Vestweber
253
Eric A Severson and Charles A Parkos
271
Karyn Yonekawa and John M Harlan
289
Index
305
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