Adhesion Molecules and the Lung

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CRC Press, Jan 23, 1996 - Science - 432 pages
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This state-of-the-art reference outlines current knowledge of the structure, transcriptional regulation, and binding characteristics of vascular and leukocyte adhesion molecules and their ligands delineating the nature of adhesion molecule interactions in lung morphogenesis and repair, tumor metastasis, and experimental models of inflammatory lung injury.
 

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Contents

Structural Basis and Regulation of 82Integrin Interactions
1
Selectins
43
Signal Transduction and Leukocyte Adhesion Molecules
63
Adhesion Molecules in Lung Morphogenesis
99
Interactions Between Pulmonary Epithelial Cells
127
Adhesion Molecules and Respiratory Pathogens
147
Adhesion Molecules in Experimental Lung
159
Sequence of AdhesionPromoting and Related
169
Role of ICAM1 in Airway and Parenchymal Inflammation and Dysfunction
243
Discovery and Characteristics of ICAM1
244
Expression and Role of ICAM1
245
Evidence for Role of ICAM1 in Disease
250
Conclusions
256
References
257
Role of as Integrins in Pulmonary Inflammation
267
Sheep Allergy to Ascaris Antigen
269

Cell Adhesion in Wound Healing and Pulmonary Fibrosis
177
Cell Adhesion Molecules in Human Fibrotic Lung Disease
191
Conclusions and Therapeutic Implications
192
References
195
Endothelial Cell Adhesion Molecules and Pulmonary Metastasis
211
The Role of Constitutive Lung Endothelial Cell Adhesion Molecules in Cancer Metastasis
213
The Role of Inducible Endothelial Cell Adhesion Molecules in Cancer Metastasis
221
The Dynamics of Tumor CellEndothelial Cell Adhesion
224
Heterotypic Communication Between Tumor Cells and Endothelial Cells and Signal Transduction
225
Therapeutic Implications
228
Conclusion and Future Investigations
229
References
231
OvalbuminInduced Asthma in the Rat
270
Guinea Pig Models of Lung Inflammation
271
Murine Model of Allergic Asthma
272
Role of Adhesion Molecules and Cytokines
279
Summary
298
Adhesion Molecules in Bacterial Pneumonia
311
Migration of Neutrophils into the Lung Parenchyma
326
Resolution of Inflammation
333
Author Index
359
Subject Index
397
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