Adipose Tissue Development: From Animal Models to Clinical Conditions
Claire Levy-Marchal, Luc Pénicaud
Karger Medical and Scientific Publishers, 2010 - Medical - 96 pages
Nowadays, adipose tissue is not only regarded as an organ of storage related to fuel metabolism but also as an endocrine organ involved in the regulation of insulin sensitivity, lipids and energy metabolism.These proceedings cover the nervous regulation of both white and brown adipose tissue mass. Different physiological parameters such as metabolism (lipolysis and thermogenesis) and secretory activity (leptin and other adipokines) are reviewed. The plasticity of adipose tissue (proliferation, differentiation and apoptosis) showing the presence of a neural feedback loop between adipose tissue and the brain, which plays a major role in the regulation of energy homeostasis, is discussed.Merging basic knowledge and various clinical conditions, this thorough review is of great interest to both scientists and physicians, in particular pediatricians, interested in obesity, endocrinology and nutrition.
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adipocytes adipokines adiponectin Adipose Tissue Development adolescents adult adulthood apoptosis associated Barb CR Barker DJ Basel birth weight body fat body mass index born SGA breast cancer brown adipocytes cancer cells Capeau cardiovascular risk factors Casteilla catch-up growth childhood Clin Endocrinol Metab clinical clustering cohort cytokines decreased demonstrated differentiation disease dyslipidemia early effects Endocr energy fat depots fat mass fatty acids fetal growth FPLD2 function gene expression genetic gestational age hormone human hyperinsulinemia hypothalamic increased infants innervation insulin resistance insulin sensitivity intake Karger kisspeptin lamin A/C laminopathies leptin Levy-Marchal lipid lipoatrophy liver LMNA metabolic alterations metabolic syndrome muscle nesfatin-1 neuropeptide obese children obesity Ong KK partial lipodystrophy pathways patients Pénicaud phenotype Physiol physiological porcine postnatal preadipocytes protein puberty receptor regulation role secretion stem cells steroidogenesis studies subcutaneous tion triglyceride tumor progression type 2 diabetes visceral fat vitro weight gain white adipocytes white adipose tissue